1. Epigenetics
  2. Histone Methyltransferase
  3. PRMT5-IN-1

PRMT5-IN-1 

Cat. No.: HY-126256
Handling Instructions

PRMT5 IN-1, a hemiaminal, is a covalent protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 11 nM for PRMT5/MEP50. PRMT5 IN-1 can be converted to aldehydes and react with C449 to form covalent adducts under physiological conditions.

For research use only. We do not sell to patients.

PRMT5-IN-1 Chemical Structure

PRMT5-IN-1 Chemical Structure

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Description

PRMT5 IN-1, a hemiaminal, is a covalent protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 11 nM for PRMT5/MEP50. PRMT5 IN-1 can be converted to aldehydes and react with C449 to form covalent adducts under physiological conditions[1].

IC50 & Target

IC50: 11 nM (PRMT5)[1]

Molecular Weight

418.83

Formula

C₁₉H₁₉ClN₄O₅

SMILES

O[[email protected]@H]1[[email protected]@H]([[email protected]@H](C2=CC=C(Cl)C=C2)O)O[[email protected]@H](N3C=CC4=C3N=CN5C4=NCC5O)[[email protected]@H]1O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
PRMT5-IN-1
Cat. No.:
HY-126256
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