2366149-83-7
Chemical Structure
PRMT5-IN-1
- CAS No.: 2366149-83-7
- Formula:C19H19ClN4O5
- Molecular Weight:418.83
IUPAC Name: (2R,3S,4R,5R)-2-((R)-(4-chlorophenyl)(hydroxy)methyl)-5-(3-hydroxy-2,3-dihydro-7H-imidazo[1,2-c]pyrrolo[3,2-e]pyrimidin-7-yl)tetrahydrofuran-3,4-diol
InChIKey: LTPABOINPMWTKU-BHUSIORFSA-N
SMILES: O[C@@H]1[C@@H]([C@@H](C2=CC=C(Cl)C=C2)O)O[C@@H](N3C=CC4=C3N=CN5C4=NCC5O)[C@@H]1O
Biological Activity: PRMT5 IN-1, a hemiaminal, is a potent, selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 11 nM for PRMT5/MEP50. PRMT5 IN-1 can be converted to aldehydes and react with C449 to form covalent adducts under physiological conditions[1].
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PRMT5-IN-1 | PRMT5 IN-1, a hemiaminal, is a potent, selective protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 11 nM for PRMT5/MEP50. PRMT5 IN-1 can be converted to aldehydes and react with C449 to form covalent adducts under physiological conditions. | |||||||||||||||||||||
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Keywords
