COPRS - coordinator of PRMT5 and differentiation stimulator Gene

Also Known as TTP1; COPR5; C17orf79; HSA272196

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55352

About COPRS

This gene has 5 transcripts (splice variants) and 93 orthologues. Broad expression in testis (RPKM 66.1), brain (RPKM 19.5) and 22 other tissues.

Summary

Enables histone binding activity. Involved in histone H4-R3 methylation. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

COPRS Products (2)

mRNA Protein Name
NM_001330176.2 NP_001317105.1 coordinator of PRMT5 and differentiation stimulator isoform 2
NM_018405.4 NP_060875.2 coordinator of PRMT5 and differentiation stimulator isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone binding IDA
IDA: Inferred from direct assay
18404153 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18404153 GOA
Biological Process GO Annotation Evidence References Source
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
18404153 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
18404153 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COPRS Protein Structure

COPR5

COPR5: Cooperator of PRMT5 family (33 - 184)

  • 0
  • 100
  • 184 a.a.
Protein Preferred Names Protein Names

coordinator of PRMT5 and differentiation stimulator

  • cooperator of PRMT5

COPRS Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
COPRS Q9NQ92 H4C16 Homo sapiens P62805
Far-WB
18404153
Intra
COPRS Q9NQ92 H4C16 Homo sapiens P62805
Pull Down
18404153
Intra
COPRS Q9NQ92 PRMT5 Homo sapiens O14744
Y2H
18404153
Intra
COPRS Q9NQ92 PRMT5 Homo sapiens O14744
Pull Down
18404153
Intra
COPRS Q9NQ92 PRMT5 Homo sapiens O14744
Anti Tag CoIP
33961781
Intra
COPRS Q9NQ92 PRMT5 Homo sapiens O14744
Anti Tag CoIP
18404153
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Chromosome 17q11.2 Deletion Syndrome

  • Nf1 Microdeletion Syndrome

  • 17q11 Microdeletion Syndrome

  • Neurofibromatosis Type 1 Microdeletion Syndrome

  • Van Asperen Syndrome

  • Del(17)(Q11)

  • Monosomy 17q11

  • Chromosome 17q11.2 Deletion Syndrome, 1.4mb
Palmoplantar Keratoderma, Bothnian Type

  • PPKB

  • Diffuse Palmoplantar Keratoderma, Bothnian Type

  • Bothnian Type Palmoplantar Keratoderma

  • Keratoderma, Palmoplantar, Bothnian Type

  • Palmoplantar Keratoderma, Nonepidermolytic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03026 COPRS Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus COPRS RGD RGD:1565675
Bos taurus COPRS VGNC VGNC:27598
Canis familiaris COPRS VGNC VGNC:55562
Macaca mulatta COPRS VGNC VGNC:71367
Felis catus COPRS VGNC VGNC:61086
Mus musculus COPRS MGD MGI:1913673
Others COPRS NCBI