RBM23 - RNA binding motif protein 23 Gene

Also Known as PP239; RNPC4; CAPERbeta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55147

About RBM23

This gene has 33 transcripts (splice variants), 99 orthologues and 36 paralogues. Ubiquitous expression in thyroid (RPKM 14.7), ovary (RPKM 12.8) and 25 other tissues.

Summary

This gene encodes a member of the U2AF-like family of RNA binding proteins. This protein interacts with some steroid nuclear receptors, localizes to the promoter of a steroid- responsive gene, and increases transcription of steroid-responsive transcriptional reporters in a hormone-dependent manner. It is also implicated in the steroid receptor-dependent regulation of alternative splicing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RBM23 Products (9)

mRNA	Protein	Name
NM_001077351.2	NP_001070819.1	probable RNA-binding protein 23 isoform 1
NM_001077352.2	NP_001070820.1	probable RNA-binding protein 23 isoform 3
NM_001308044.2	NP_001294973.1	probable RNA-binding protein 23 isoform 4
NM_001352762.2	NP_001339691.1	probable RNA-binding protein 23 isoform 4
NM_001352763.2	NP_001339692.1	probable RNA-binding protein 23 isoform 1
NM_001352764.2	NP_001339693.1	probable RNA-binding protein 23 isoform 5
NM_001352765.2	NP_001339694.1	probable RNA-binding protein 23 isoform 2
NM_001352766.2	NP_001339695.1	probable RNA-binding protein 23 isoform 1
NM_018107.5	NP_060577.3	probable RNA-binding protein 23 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22365833	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15694343	GOA
involved in regulation of mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	15694343	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM23 Protein Structure

RRM_1

RBM39linker

0
100
200
300
400
439 a.a.

Protein Preferred Names	Protein Names
probable RNA-binding protein 23	CAPER beta

RBM23 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RBM23	Q86U06	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	25416956
Intra	RBM23	Q86U06	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
Intra	RBM23	Q86U06	MAGEA11	Homo sapiens	P43364-2	Y2H Array	25416956
Intra	RBM23	Q86U06	PRMT5	Homo sapiens	O14744	Y2H	23455924
Intra	RBM23	Q86U06	SRPK2	Homo sapiens	P78362	Anti Tag CoIP	33961781
Intra	RBM23	Q86U06	SRPK2	Homo sapiens	P78362	Y2H	22365833
Intra	RBM23	Q86U06	BHLHE40	Homo sapiens	O14503	Validated Y2H	25416956
Intra	RBM23	Q86U06	BHLHE40	Homo sapiens	O14503	Y2H Prey Pooling	25416956
Intra	RBM23	Q86U06	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	RBM23	Q86U06	TRIM27	Homo sapiens	P14373	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Posterior Uveal Melanoma	Medium/Large Size Posterior Uveal Melanoma Small Size Posterior Uveal Melanoma Ciliary Body And Choroid Melanoma, Medium/Large Size Ciliary Body And Choroid Melanoma, Small Size

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-177779	dRRM-1		/	Unkown
HY-RS11741	RBM23 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown