MS4322 (isomer)
Based on 1 Customer Validation
MS4322 (YS43-22) isomer is an isomer of MS4322. MS4322 is a specific PRMT5 PROTAC degrader. MS4322 reduces the PRMT5 protein level with a DC50 of 1.1 μM in MCF-7 cells. MS4322 inhibits the methyltransferase activity of PRMT5 with an IC50 of 18 nM. MS4322 promotes ubiquitination and degradation of PRMT5. MS4322 can be used for the research of breast cancer, lung cancer, and hepatocellular cancer.
(Pink: PRMT5 ligand (HY-173092); Blue: VHL ligand (HY-112078); Black: linker (HY-124780)).
For research use only. We do not sell to patients.
- Purity: 99.87%
- CAS No.: 2601727-80-2
- Formula: C55H76N10O12S
- Molecular Weight:1101.32
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
(Pink: PRMT5 ligand (HY-173092); Blue: VHL ligand (HY-112078); Black: linker (HY-124780)).
|
VHL |
Cereblon |
MDM2 |
SMYD2 |
SMYD3 |
EHMTI PEP |
SETD7/KMT7 |
PRMT4 |
PRMT8 |
EZH1 |
SETDB1/KMT2G |
SETD8/KMT5A |
PRMT5 |
EZH2 |
SUV39H2/KMT1B |
SETD2/KMT3A |
PRMT1 |
PRMT6 |
DOT1L |
EHMT2/G9a/KMT1C |
NSD2 |
PRMT3 |
PRMT7 |
Chemical Information
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CAS No. 2601727-80-2
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Appearance Solid
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Molecular Weight 1101.32
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Formula C55H76N10O12S
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Color White to off-white
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SMILES
O=C(N1CC(C1)NC2=NC=NC(C(NC[C@H](O)CN3CC4=CC=CC=C4CC3)=O)=C2)COCCOCCOCCOCCOCC(N[C@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(N[C@@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)=O)=O
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Synonyms
YS43-22 (isomer)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (45.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9080 mL | 4.5400 mL | 9.0800 mL | 22.7000 mL |
| 5 mM | 0.1816 mL | 0.9080 mL | 1.8160 mL | 4.5400 mL | |
| 10 mM | 0.0908 mL | 0.4540 mL | 0.9080 mL | 2.2700 mL | |
| 15 mM | 0.0605 mL | 0.3027 mL | 0.6053 mL | 1.5133 mL | |
| 20 mM | 0.0454 mL | 0.2270 mL | 0.4540 mL | 1.1350 mL | |
| 25 mM | 0.0363 mL | 0.1816 mL | 0.3632 mL | 0.9080 mL | |
| 30 mM | 0.0303 mL | 0.1513 mL | 0.3027 mL | 0.7567 mL | |
| 40 mM | 0.0227 mL | 0.1135 mL | 0.2270 mL | 0.5675 mL |
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