2. Epigenetics
  3. Histone Methyltransferase
  4. (S)-MRTX-1719

(S)-MRTX-1719 (example 16-7) is the S-enantiomer of MRTX-1719. (S)-MRTX-1719 is a PRMT5/MTA complex inhibitor, with an IC50 of 7070 nM.

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(S)-MRTX-1719 Chemical Structure

(S)-MRTX-1719 Chemical Structure

CAS No. : 2630904-44-6

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Based on 1 publication(s) in Google Scholar

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Description

(S)-MRTX-1719 (example 16-7) is the S-enantiomer of MRTX-1719. (S)-MRTX-1719 is a PRMT5/MTA complex inhibitor, with an IC50 of 7070 nM[1].

IC50 & Target

PRMT5

 

Molecular Weight

464.88

Formula

C23H18ClFN6O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

FC1=C(C=C(C(C#N)=[C@@]1[C@@]2=C(C3=CC=C4C(C(CN)=NNC4=O)=C3)C=NN2C)OC5CC5)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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(S)-MRTX-1719 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-MRTX-17192630904-44-6Histone MethyltransferaseNSCLCCRCPRMT5MTAHCT116Inhibitorinhibitorinhibit

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