PRMT5-MTA-IN-5
PRMT5-MTA-IN-5 (Compound 7) is an orally active, irreversible PRMT5-MTA complex (PRMT5•MTA) inhibitor (IC50=1.15 nM). PRMT5-MTA-IN-5 blocks arginine methylation and inhibits ribosomal RNA processing and cell cycle-related protein expression. PRMT5-MTA-IN-5 potently inhibits proliferation in MTAP-deficient tumor cells. PRMT5-MTA-IN-5 is promising for research of MTAP-deficient solid tumors, such as liver, breast, and pancreatic cancers.
For research use only. We do not sell to patients.
- CAS No.: 3078322-88-7
- Formula: C27H24FN7O
- Molecular Weight:481.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Histone Methyltransferase Isoforms
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Biological Activity
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PRMT5 1.15 nM (IC50) |
Chemical Information
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CAS No. 3078322-88-7
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Molecular Weight 481.52
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Formula C27H24FN7O
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SMILES
NCC1=NNC(C2=C(C=C)C=C(C3=[C@]([C@]4=C(C#N)C(N5CC(C5)=C)=CC(C)=C4F)N(C)N=C3)C=C21)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PRMT5-MTA-IN-5 Related Classifications
HY-176702 Related Classifications
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