2. Epigenetics
  3. Histone Methyltransferase
  4. PRMT5-IN-34

PRMT5-IN-34 (Compound C) is an inhibitor of MTA-cooperative Protein arginine methyltransferase 5 (PRMT5/MAT).

For research use only. We do not sell to patients.

PRMT5-IN-34 Chemical Structure

PRMT5-IN-34 Chemical Structure

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PRMT5-IN-34 Related Antibodies

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Description

PRMT5-IN-34 (Compound C) is an inhibitor of MTA-cooperative Protein arginine methyltransferase 5 (PRMT5/MAT)[1].

IC50 & Target[1]

PRMT5

 

In Vitro

PRMT5-IN-34 inhibits each cell proliferation activity with IC50=0.827 μM (HDLM2), 0.252 μM (L540), 0.077 μM (L1236), 4.638 μM (L428), 0.170 μM (HCT116), 8.538 μM (HCT116) and 0.538 μM (HCT116), respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PRMT5-IN-34 Related Antibodies
In Vivo

PRMT5-IN-34 (p.o.; 25-100 mg/kg; once daily for 21 days) inhibits tumor growth and decreases SDMA protein levels in the MTAP-silenced L540HL xenograft mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MTAP silenced L540 HL xenograft model [1]
Dosage: 25; 50; 100 mg/kg
Administration: p.o. once daily for 21 days
Result: Concentration-dependently inhibited tumor growth (22%, 52%, 93%). Concentration-dependently decreased the protein level of SDMA (83.9%, 97.6%, 99.1%).
Molecular Weight

435.43

Formula

C23H19F2N5O2
Unlabeled Cas

SMILES

CC#CCN1CC[C@]2(C3=CC=C(C=C3C(N2CC4=CC5=C(N4)C=C(C(N)=N5)F)=O)F)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PRMT5-IN-34 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PRMT5-IN-34Histone Methyltransferasecancer L540 HL xenograft modelInhibitorinhibitorinhibit

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PRMT5-IN-34
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HY-158143
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