RAPRMT5
RAPRMT5 is a PRMT5 CAP-TAC (proteinase complex-targeted chimeric agent) degrader. RAPRMT5 can induce PRMT5 to undergo proteasome-dependent, ubiquitin-independent degradation. RAPRMT5 can be used in the research of various cancers.
(Pink: PRMT5 ligand (HY-181522); Blue: Proteasome ligand (HY-181523); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 2721998-42-9
- Formula: C54H58N10O10
- Molecular Weight:1007.10
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Histone Methyltransferase Isoforms
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Biological Activity
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PRMT5 |
RAPRMT5 (0.1-10 μM; 24-48 h) induces dose-dependent degradation of PRMT5 in HEK293T cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293T
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Concentration:0.1, 0.3, 1.0, 3.0, 10 μM (24 h); 0.1, 0.3, 1.0, 3.0, 10 μM (48 h)
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Incubation Time:24 h; 48 h
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Result:Decreased PRMT5 protein levels in HEK293T cells at all tested concentrations after 24 and 48 h of treatment.
Chemical Information
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CAS No. 2721998-42-9
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Molecular Weight 1007.10
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Formula C54H58N10O10
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SMILES
O=C(N1C/C(C(/C(C1)=C/C2=CC=C([N+]([O-])=O)C=C2)=O)=C\C3=CC=C([N+]([O-])=O)C=C3)[C@@H](NC(CCCCCCNC(CNC4=CC(C(NC[C@H](O)CN5CC(C=CC=C6)=C6CC5)=O)=NC=N4)=O)=O)CC7=CC=CC=C7
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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