2. PROTAC Epigenetics Metabolic Enzyme/Protease
  3. Proteasome Cap Targeting Chimeras Histone Methyltransferase Proteasome
  4. RAPRMT5

RAPRMT5 is a PRMT5 CAP-TAC (proteinase complex-targeted chimeric agent) degrader. RAPRMT5 can induce PRMT5 to undergo proteasome-dependent, ubiquitin-independent degradation. RAPRMT5 can be used in the research of various cancers.
(Pink: PRMT5 ligand (HY-181522); Blue: Proteasome ligand (HY-181523); Black: linker).

For research use only. We do not sell to patients.

RAPRMT5

RAPRMT5 Chemical Structure

CAS No. : 2721998-42-9

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RAPRMT5 Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 NSD3/WHSC1L1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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Description

RAPRMT5 is a PRMT5 CAP-TAC (proteinase complex-targeted chimeric agent) degrader. RAPRMT5 can induce PRMT5 to undergo proteasome-dependent, ubiquitin-independent degradation. RAPRMT5 can be used in the research of various cancers[1]. (Pink: PRMT5 ligand (HY-181522); Blue: Proteasome ligand (HY-181523); Black: linker).

IC50 & Target[1]

PRMT5

 

In Vitro

RAPRMT5 (0.1-10 μM; 24-48 h) induces dose-dependent degradation of PRMT5 in HEK293T cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RAPRMT5 Related Antibodies

Western Blot Analysis[1]

Cell Line: HEK293T
Concentration: 0.1, 0.3, 1.0, 3.0, 10 μM (24 h); 0.1, 0.3, 1.0, 3.0, 10 μM (48 h)
Incubation Time: 24 h; 48 h
Result: Decreased PRMT5 protein levels in HEK293T cells at all tested concentrations after 24 and 48 h of treatment.
Molecular Weight

1007.10

Formula

C54H58N10O10
CAS No.
SMILES

O=C(N1C/C(C(/C(C1)=C/C2=CC=C([N+]([O-])=O)C=C2)=O)=C\C3=CC=C([N+]([O-])=O)C=C3)[C@@H](NC(CCCCCCNC(CNC4=CC(C(NC[C@H](O)CN5CC(C=CC=C6)=C6CC5)=O)=NC=N4)=O)=O)CC7=CC=CC=C7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RAPRMT5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RAPRMT52721998-42-9RAPRMT 5RAPRMT-5Proteasome Cap Targeting ChimerasHistone MethyltransferaseProteasomeCAP-TACsubiquitinationproteasomecancersPRMT5Proteasome Cap Targeting ChimeraHEK293T cellsInhibitorinhibitorinhibit

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