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Cat. No.: HY-181522

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PRMT5 ligand 3

PRMT5 ligand 3 (Compound S19) is a PRMT5 ligand that can be used for the synthesis of PROTACs, such as RAPRMT5 (HY-181521).

For research use only. We do not sell to patients.

CAS No.: 1616397-61-5
Formula: C₁₇H₁₉ClN₄O₂
Molecular Weight:346.81

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

PRMT5 ligand 3 Chemical Structure

CAS No.: 1616397-61-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PRMT5 ligand 3 (Compound S19) is a PRMT5 ligand that can be used for the synthesis of PROTACs, such as RAPRMT5 (HY-181521)^[1].

IC₅₀ & Target^[1]

PRMT5

All Histone Methyltransferase Isoforms :

Chemical Information

CAS No. 1616397-61-5
Molecular Weight 346.81
Formula C₁₇H₁₉ClN₄O₂
SMILES

ClC1=CC(C(NC[C@H](O)CN2CC(C=CC=C3)=C3CC2)=O)=NC=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Song C, et al. Proteasome Cap Targeting Chimeras for Ubiquitination-Independent Targeted Protein Degradation. Angew Chem Int Ed Engl. 2026 Feb 23;65(9):e20039. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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