PRMT5-MTA-IN-4
PRMT5-MTA-IN-4 (Compound 30) is a potent irreversible protein arginine methyltransferase 5 (PRMT5) inhibitor (IC50=8 nM). PRMT5-MTA-IN-4 blocks arginine methylation, inhibiting ribosomal RNA processing and cell cycle-related protein expression. PRMT5-MTA-IN-4 exhibits antiproliferative activity in multiple tumor cell lines (e.g., IC50=0.3 μM in DLD-1 cells). PRMT5-MTA-IN-4 is promising for research of hematological malignancies, such as acute myeloid leukemia, diffuse large B-cell lymphoma.
For research use only. We do not sell to patients.
- CAS No.: 3025838-18-7
- Formula: C26H22ClFN6O2
- Molecular Weight:504.94
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Histone Methyltransferase Isoforms
More
Biological Activity
|
PRMT5 8 nM (IC50) |
Chemical Information
-
CAS No. 3025838-18-7
-
Molecular Weight 504.94
-
Formula C26H22ClFN6O2
-
SMILES
NCC1=NNC(C2=C(C=C)C=C(C3=[C@]([C@]4=C(C#N)C(OC5(C)CC5)=CC(Cl)=C4F)N(C)N=C3)C=C21)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz