1. Epigenetics
  2. Histone Methyltransferase
  3. PRMT4-IN-1

PRMT4-IN-1 

Cat. No.: HY-146810
Handling Instructions

PRMT4-IN-1 is a selective inhibitor of PRMT4 (IC50=3.2 nM). PRMT4-IN-1 inhibits MCF7 relative viability.

For research use only. We do not sell to patients.

PRMT4-IN-1 Chemical Structure

PRMT4-IN-1 Chemical Structure

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Description

PRMT4-IN-1 is a selective inhibitor of PRMT4 (IC50=3.2 nM). PRMT4-IN-1 inhibits MCF7 relative viability[1].

IC50 & Target[1]

PRMT1

0.835 μM (IC50)

PRMT3

4.05 μM (IC50)

PRMT4

3.2 nM (IC50)

PRMT5

1.46 μM (IC50)

PRMT6

1.75 μM (IC50)

PRMT7

1.68 μM (IC50)

PRMT8

1.95 μM (IC50)

In Vitro

PRMT4-IN-1 (compound 12h) (10 μM, 50 μM, 100 μM; 24 h, 72 h) shows no effect on reduction the number of metabolically active cells[1]. PRMT4-IN-1 (50 μM; 2-8 d) decreases relative cell viability time-dependently in MCF7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

648.67

Formula

C30H36N10O7

SMILES

O=C(OC)C1=CC(O)=C2C=C(NC(NCCCCNC(NC/C=C/[C@H]3O[C@@H](N4C=NC5=C(N)N=CN=C45)[C@H](O)[C@@H]3O)=N)=O)C=CC2=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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PRMT4-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
PRMT4-IN-1
Cat. No.:
HY-146810
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