2. Epigenetics
  3. Histone Methyltransferase
  4. PRMT4-IN-1

PRMT4-IN-1 is a selective inhibitor of PRMT4 (IC50=3.2 nM). PRMT4-IN-1 inhibits MCF7 relative viability.

For research use only. We do not sell to patients.

PRMT4-IN-1 Chemical Structure

PRMT4-IN-1 Chemical Structure

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PRMT4-IN-1 Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PRMT4-IN-1 is a selective inhibitor of PRMT4 (IC50=3.2 nM). PRMT4-IN-1 inhibits MCF7 relative viability[1].

IC50 & Target[1]

PRMT1

0.835 μM (IC50)

PRMT3

4.05 μM (IC50)

PRMT4

3.2 nM (IC50)

PRMT5

1.46 μM (IC50)

PRMT6

1.75 μM (IC50)

PRMT7

1.68 μM (IC50)

PRMT8

1.95 μM (IC50)

In Vitro

PRMT4-IN-1 (compound 12h) (10 μM, 50 μM, 100 μM; 24 h, 72 h) shows no effect on reduction the number of metabolically active cells[1]. PRMT4-IN-1 (50 μM; 2-8 d) decreases relative cell viability time-dependently in MCF7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PRMT4-IN-1 Related Antibodies
Molecular Weight

648.67

Formula

C30H36N10O7
SMILES

O=C(OC)C1=CC(O)=C2C=C(NC(NCCCCNC(NC/C=C/[C@H]3O[C@@H](N4C=NC5=C(N)N=CN=C45)[C@H](O)[C@@H]3O)=N)=O)C=CC2=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PRMT4-IN-1 Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PRMT4-IN-1Histone MethyltransferaseMCF-7 cellsbreast cancerInhibitorinhibitorinhibit

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HY-146810
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