3035425-70-5
3035425-70-5
Chemical Structure
PRMT4-IN-1
- CAS 番号: 3035425-70-5
- Formula:C30H36N10O7
- Molecular Weight:648.67
IUPAC Name: 4-(((3R,5S)-3,5-dimethylpiperidin-1-yl)sulfonyl)-N-(5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2-yl)benzamide
InChIKey: JYIRWTZMMGLPFI-HMZLUZKYSA-N
SMILES: O[C@@H]1[C@H](O)[C@@H](/C=C/CNC(NCCCCNC(NC2=CC3=C(O)C=C(C(OC)=O)C=C3C=C2)=O)=N)O[C@H]1N4C=NC5=C(N)N=CN=C45
Biological Activity: PRMT4-IN-1 is a selective inhibitor of PRMT4 (IC50=3.2 nM). PRMT4-IN-1 inhibits MCF7 relative viability[1].
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PRMT4-IN-1 | PRMT4-IN-1 is a selective inhibitor of PRMT4 (IC50=3.2 nM). PRMT4-IN-1 inhibits MCF7 relative viability. | |||||||||||||||||||||
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References
- [1]. Iannelli G, et al. Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach. J Med Chem. 2022 Sep 8;65(17):11574-11606. [Content Brief]
