2. Epigenetics
  3. Histone Methyltransferase
  4. TNG908

TNG908 is a MTAP synergistic PRMT5 inhibitor. TNG908 crosses the blood-brain barrier and is orally active. TNG908 could be used in cancer research.

For research use only. We do not sell to patients.

TNG908 Chemical Structure

TNG908 Chemical Structure

CAS No. : 2760481-53-4

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1 mg USD 520 In-stock
5 mg USD 1150 In-stock
10 mg USD 1840 In-stock
25 mg USD 3680 In-stock
50 mg USD 5900 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

TNG908 Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TNG908 is a MTAP synergistic PRMT5 inhibitor. TNG908 crosses the blood-brain barrier and is orally active. TNG908 could be used in cancer research[1].

IC50 & Target

PRMT5

 

In Vitro

TNG908 (0-10 μM, 24 h) is 15 times more selective for MTAPnull cell lines than MTAPWT cell lines, and the stability of human liver microsomes is C< sub>lint=14 μL/min/mg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TNG908 Related Antibodies

Western Blot Analysis[1]

Cell Line: SDMA cell，HAP1 MTAP WT and MTAP-null In-Cell
Concentration: 0-10 μM
Incubation Time: 24 h
Result: Had an IC50 value of 0.009μM for PRMT5 in SDMA cells.
In Vivo

TNG908 (1-120 mg/kg twice daily for 21 days, p.o. or i.v.) A promotes tumor regression in LU99 NSCLC cell line-derived xenograft mouse model[1].

Pharmacokinetic Analysis in SD Rats[1]

Route Dose (mg/kg) clearance (mL/min/kg) Vss_obs (L/kg) T1/2 (h) Cmax (μg/mL) AUCINF (μg·h/mL)
p.o. 1 38.2 1.5 2 / /
p.o. 3 / / / 0.6 2.5

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

409.50

Formula

C21H23N5O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=CC(NC(C(N2[C@@H](C3=CC=C(SC=N4)C4=C3)CC[C@@H](C2)C)=O)=O)=CN=C1N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (244.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4420 mL 12.2100 mL 24.4200 mL
5 mM 0.4884 mL 2.4420 mL 4.8840 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.89%

COA (256 KB) HNMR (146 KB) RP-HPLC (142 KB) LCMS (417 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4420 mL 12.2100 mL 24.4200 mL 61.0501 mL
5 mM 0.4884 mL 2.4420 mL 4.8840 mL 12.2100 mL
10 mM 0.2442 mL 1.2210 mL 2.4420 mL 6.1050 mL
15 mM 0.1628 mL 0.8140 mL 1.6280 mL 4.0700 mL
20 mM 0.1221 mL 0.6105 mL 1.2210 mL 3.0525 mL
25 mM 0.0977 mL 0.4884 mL 0.9768 mL 2.4420 mL
30 mM 0.0814 mL 0.4070 mL 0.8140 mL 2.0350 mL
40 mM 0.0611 mL 0.3053 mL 0.6105 mL 1.5263 mL
50 mM 0.0488 mL 0.2442 mL 0.4884 mL 1.2210 mL
60 mM 0.0407 mL 0.2035 mL 0.4070 mL 1.0175 mL
80 mM 0.0305 mL 0.1526 mL 0.3053 mL 0.7631 mL
100 mM 0.0244 mL 0.1221 mL 0.2442 mL 0.6105 mL
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TNG908 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNG9082760481-53-4TNG 908TNG-908Histone MethyltransferasePRMT5MTAPblood-brain barriercancerInhibitorinhibitorinhibit

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