ELOA - elongin A Gene

Homo sapiens

Also known as SIII; TCEB3; TCEB3A; SIII p110

Gene ID: 6924 | Gene type: protein coding

About ELOA

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:23,743,471-23,762,059 (from NCBI)

This gene has 4 transcripts (splice variants), 176 orthologues and 1 paralogue. Ubiquitous expression in lung (RPKM 15.9), thyroid (RPKM 14.1) and 25 other tissues.

Summary

This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008]

ELOA Products(1)

mRNA	Protein	Name
NM_003198.3	NP_003189.3	elongin-A

ELOA Protein Structure

Med26

Elongin_A

0
200
400
600
798 a.a.

Protein Preferred Names

Protein Names

elongin-A

RNA polymerase II transcription factor SIII subunit A1

Related Diseases

Diseases

Alias

Cockayne Syndrome B

Cockayne Syndrome Type 2	Cockayne Syndrome, Type B
Cockayne Syndrome Type Ii	CSB
Cockayne Syndrome 2	Cockayne Syndrome Type B
Ckn2	Cockayne Syndrome, Type Ii

Cockayne Syndrome A

Cockayne Syndrome Type 1	Cockayne Syndrome, Type A
Cockayne Syndrome Type I	CSA
Cockayne Syndrome Classic Form	Cockayne Syndrome Classical
Cockayne Syndrome Type A	Ckn1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04317	ELOA Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ELOA	VGNC	VGNC:72035
Mus musculus	ELOA	MGD	MGI:1351315
Bos taurus	ELOA	VGNC	VGNC:56105
Rattus norvegicus	ELOA	RGD	RGD:3827
Canis familiaris	ELOA	VGNC	VGNC:54720
Others	ELOA	NCBI