CNTROB - centrobin, centriole duplication and spindle assembly protein Gene

Also Known as LIP8; PP1221

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 116840

Summary

This gene encodes a centrosomal protein that interacts with BRCA2, and is required for centriole duplication and cytokinesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Broad expression in testis (RPKM 22.1), endometrium (RPKM 9.7) and 24 other tissues.

CNTROB Products (1)

mRNA Protein Name
NG_029754.2 [RefSeqGene]

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16275750 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
11984006 GOA
Biological Process GO Annotation Evidence References Source
involved in centriole replication IMP
IMP: Inferred from mutant phenotype
16275750 GOA
involved in centrosome separation IMP
IMP: Inferred from mutant phenotype
16275750 GOA
involved in mitotic cytokinetic process IMP
IMP: Inferred from mutant phenotype
16275750 GOA
Cellular Component GO Annotation Evidence References Source
located in centriole IDA
IDA: Inferred from direct assay
16275750 GOA
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
located in centrosome IMP
IMP: Inferred from mutant phenotype
21576394 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNTROB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CNTROB Q8N137 COASY Homo sapiens Q13057-2
Validated Y2H
25416956
Intra
CNTROB Q8N137 COASY Homo sapiens Q13057-2
Y2H Prey Pooling
25416956
Intra
CNTROB Q8N137 COASY Homo sapiens Q13057-2
Y2H Array
25416956
Intra
CNTROB Q8N137 PNKP Homo sapiens Q96T60
Validated Y2H
32296183
Intra
CNTROB Q8N137 TSHZ2 Homo sapiens Q9NRE2
Validated Y2H
32296183
Intra
CNTROB Q8N137 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
32296183
Intra
CNTROB Q8N137 CAD Homo sapiens P27708
Anti Bait CoIP
35709258
Intra
CNTROB Q8N137 PELI1 Homo sapiens Q96FA3
Validated Y2H
32296183
Intra
CNTROB Q8N137 TTC23 Homo sapiens Q5W5X9
Y2H Array
25416956
Intra
CNTROB Q8N137 TTC23 Homo sapiens Q5W5X9
Y2H Prey Pooling
25416956
Intra
CNTROB Q8N137 TTC23 Homo sapiens Q5W5X9
Validated Y2H
25416956
Intra
CNTROB Q8N137 RSPH14 Homo sapiens Q9UHP6
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction