MCRS1 - microspherule protein 1 Gene

Homo sapiens

Also known as P78; MCRS2; MSP58; INO80Q; ICP22BP

Gene ID: 10445 | Gene type: protein coding

About MCRS1

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:49,558,299-49,568,142 (from NCBI)

This gene has 16 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in heart (RPKM 7.8), thyroid (RPKM 7.5) and 25 other tissues.

Summary

Enables RNA binding activity and Telomerase Inhibitor activity. Involved in histone H4 acetylation; negative regulation of DNA metabolic process; and positive regulation of protein localization to nucleolus. Located in cytoplasm; nucleolus; and nucleoplasm. Part of Ino80 complex; MLL1 complex; and Histone Acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

MCRS1 Products(3)

mRNA	Protein	Name
NM_001012300.1	NP_001012300.1	microspherule protein 1 isoform 2
NM_001278341.2	NP_001265270.1	microspherule protein 1 isoform 3
NM_006337.5	NP_006328.2	microspherule protein 1 isoform 1

MCRS1 Protein Structure

MCRS_N

FHA

0
100
200
300
400
462 a.a.

Protein Preferred Names

Protein Names

microspherule protein 1

58 kDa microspherule protein

Related Diseases

Diseases

Alias

Pigmented Basal Cell Carcinoma

Skin Pigmented Basal Cell Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08248	MCRS1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MCRS1	VGNC	VGNC:43093
Rattus norvegicus	MCRS1	RGD	RGD:1311607
Macaca mulatta	MCRS1	VGNC	VGNC:74688
Mus musculus	MCRS1	MGD	MGI:1858420
Bos taurus	MCRS1	VGNC	VGNC:31323

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