MIER2 - MIER family member 2 Gene

Also Known as Mi-er2; KIAA1193

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54531

About MIER2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:305,573-344,796 (from NCBI)

This gene has 7 transcripts (splice variants), 183 orthologues and 5 paralogues. Broad expression in testis (RPKM 6.0), spleen (RPKM 3.4) and 25 other tissues.

Summary

Enables histone deacetylase binding activity. Contributes to histone deacetylase activity. Involved in histone deacetylation. Located in cytoplasm and nucleus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

MIER2 Products (8)

mRNA Protein Name
NM_001346105.2 NP_001333034.1 mesoderm induction early response protein 2 isoform 2
NM_001387152.1 NP_001374081.1 mesoderm induction early response protein 2 isoform 3
NM_001387153.1 NP_001374082.1 mesoderm induction early response protein 2 isoform 4
NM_001387154.1 NP_001374083.1 mesoderm induction early response protein 2 isoform 5
NM_001387155.1 NP_001374084.1 mesoderm induction early response protein 2 isoform 2
NM_001387156.1 NP_001374085.1 mesoderm induction early response protein 2 isoform 6
NM_001387157.1 NP_001374086.1 mesoderm induction early response protein 2 isoform 6
NM_017550.3 NP_060020.1 mesoderm induction early response protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to histone deacetylase activity IDA
IDA: Inferred from direct assay
28046085 GOA
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
28046085 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
28046085 GOA
located in nucleus IDA
IDA: Inferred from direct assay
28046085 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
28046085 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MIER2 Protein Structure

ELM2

ELM2: ELM2 domain (197 - 248)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 545 a.a.
Protein Preferred Names Protein Names

mesoderm induction early response protein 2

  • mesoderm induction early response 1, family member 2

MIER2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MIER2 Q8N344 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08443 MIER2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MIER2 RGD RGD:1307278
Macaca mulatta MIER2 VGNC VGNC:74855
Mus musculus MIER2 MGD MGI:1917677
Felis catus MIER2 VGNC VGNC:63501
Canis familiaris MIER2 VGNC VGNC:43230
Bos taurus MIER2 VGNC VGNC:31470
Others MIER2 NCBI