CAVIN2 - caveolae associated protein 2 Gene

Also Known as SDR; SDPR; PS-p68; cavin-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8436

Summary

This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation.[provided by RefSeq, Sep 2009]
Broad expression in fat (RPKM 116.9), lung (RPKM 67.0) and 17 other tissues.

CAVIN2 Products (1)

mRNA Protein Name
NM_004657.6 NP_004648.1 caveolae-associated protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables phosphatidylserine binding IDA
IDA: Inferred from direct assay
2390065 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19262564 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in plasma membrane tubulation IDA
IDA: Inferred from direct assay
19525939 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in caveola IDA
IDA: Inferred from direct assay
19525939 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
18332105 GOA
located in cytosol IDA
IDA: Inferred from direct assay
2390065 GOA
located in membrane raft IDA
IDA: Inferred from direct assay
25204797 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAVIN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
CAVIN2 O95810 A1CF Homo sapiens Q9NQ94-2
Y2H Array
25416956
Intra
CAVIN2 O95810 CAVIN1 Homo sapiens Q6NZI2
Anti Tag CoIP
24013648
Intra
CAVIN2 O95810 PLEK Homo sapiens P08567
Anti Bait CoIP
19722192
Intra
CAVIN2 O95810 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
32296183
Intra
CAVIN2 O95810 CAV1 Homo sapiens Q03135
Anti Tag CoIP
24013648
Intra
CAVIN2 O95810 CAV1 Homo sapiens Q03135
IF
19262564
Intra
CAVIN2 O95810 PLEKHF1 Homo sapiens Q96S99
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction