GPBP1 - GC-rich promoter binding protein 1 Gene

Also Known as GPBP; SSH6; VASCULIN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 65056

About GPBP1

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:57,174,059-57,264,679 (from NCBI)

This gene has 9 transcripts (splice variants), 146 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 33.9), ovary (RPKM 22.5) and 25 other tissues.

Summary

This gene was originally isolated by subtractive hybridization of cDNAs expressed in atherosclerotic plaques with a thrombus, and was found to be expressed only in vascular smooth muscle cells. However, a shorter splice variant was found to be more ubiquitously expressed. This protein is suggested to play a role in the development of atherosclerosis. Studies in mice suggest that it may also function as a GC-rich promoter-specific trans-activating transcription factor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

GPBP1 Products (5)

mRNA	Protein	Name
NM_001127235.2	NP_001120707.2	vasculin isoform 3
NM_001127236.2	NP_001120708.1	vasculin isoform 2
NM_001203246.2	NP_001190175.1	vasculin isoform 4
NM_001331037.2	NP_001317966.1	vasculin isoform 5
NM_022913.4	NP_075064.1	vasculin isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19060904	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPBP1 Protein Structure

Vasculin

0
100
200
300
400
473 a.a.

Protein Preferred Names	Protein Names
vasculin	vascular wall-linked protein

GPBP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GPBP1	Q86WP2	PRPF18	Homo sapiens	Q99633	Validated Y2H	32296183
Intra	GPBP1	Q86WP2	MCRS1	Homo sapiens	Q96EZ8	Y2H Array	19060904
Intra	GPBP1	Q86WP2	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	32296183
Intra	GPBP1	Q86WP2	MCRS1	Homo sapiens	Q96EZ8	Y2H Pooling	19060904
Intra	GPBP1	Q86WP2	NXF1	Homo sapiens	Q9UBU9	Validated Y2H	32296183
Intra	GPBP1	Q86WP2	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	25416956
Intra	GPBP1	Q86WP2	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	25416956
Intra	GPBP1	Q86WP2	FNDC11	Homo sapiens	Q9BVV2	Validated Y2H	32296183
Intra	GPBP1	Q86WP2	FNDC11	Homo sapiens	Q9BVV2	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Epilepsy, Idiopathic Generalized 17	Febrile Seizures, Familial, 2 EIG17 Familial Febrile Seizures 2 FEB2 Epilepsy, Idiopathic Generalized, Susceptibility To, 17 Familial Febrile Convulsions 2 Convulsions, Familial Febrile, 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05625	GPBP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GPBP1	VGNC	VGNC:73033
Bos taurus	GPBP1	VGNC	VGNC:29522
Felis catus	GPBP1	VGNC	VGNC:62660
Rattus norvegicus	GPBP1	RGD	RGD:1305492
Mus musculus	GPBP1	MGD	MGI:1920524
Canis familiaris	GPBP1	VGNC	VGNC:41370
Others	GPBP1	NCBI