PRPF18 - pre-mRNA processing factor 18 Gene

Also Known as PRP18; hPrp18

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8559

Summary

Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to the yeast splicing factor Prp18. [provided by RefSeq, Jul 2008]
Ubiquitous expression in fat (RPKM 3.4), brain (RPKM 3.1) and 25 other tissues.

PRPF18 Products (14)

mRNA Protein Name
NM_001395875.1 NP_001382804.1 pre-mRNA-splicing factor 18 isoform 1
NM_001395876.1 NP_001382805.1 pre-mRNA-splicing factor 18 isoform 3
NM_001395877.1 NP_001382806.1 pre-mRNA-splicing factor 18 isoform 4
NM_001395878.1 NP_001382807.1 pre-mRNA-splicing factor 18 isoform 5
NM_001395879.1 NP_001382808.1 pre-mRNA-splicing factor 18 isoform 6
NM_001395880.1 NP_001382809.1 pre-mRNA-splicing factor 18 isoform 7
NM_001395881.1 NP_001382810.1 pre-mRNA-splicing factor 18 isoform 8
NM_001395882.1 NP_001382811.1 pre-mRNA-splicing factor 18 isoform 9
NM_001395883.1 NP_001382812.1 pre-mRNA-splicing factor 18 isoform 13
NM_001395884.1 NP_001382813.1 pre-mRNA-splicing factor 18 isoform 10
NM_001395885.1 NP_001382814.1 pre-mRNA-splicing factor 18 isoform 11
NM_001395886.1 NP_001382815.1 pre-mRNA-splicing factor 18 isoform 11
NM_001395887.1 NP_001382816.1 pre-mRNA-splicing factor 18 isoform 12
NM_003675.4 NP_003666.1 pre-mRNA-splicing factor 18 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRPF18 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PRPF18 Q99633 CCDC102B Homo sapiens Q68D86
Y2H Array
32296183
Intra
PRPF18 Q99633 CCDC102B Homo sapiens Q68D86
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 KRT40 Homo sapiens Q6A162
Y2H Array
32296183
Intra
PRPF18 Q99633 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 NECAB2 Homo sapiens Q7Z6G3-2
Y2H Array
32296183
Intra
PRPF18 Q99633 NECAB2 Homo sapiens Q7Z6G3-2
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 CADPS Homo sapiens A2RRN7
Y2H Array
32296183
Intra
PRPF18 Q99633 CADPS Homo sapiens A2RRN7
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 FAM22F Homo sapiens B7ZLH0
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 FAM22F Homo sapiens B7ZLH0
Y2H Array
32296183
Intra
PRPF18 Q99633 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
PRPF18 Q99633 OSBPL3 Homo sapiens Q9H4L5
Y2H Array
32296183
Intra
PRPF18 Q99633 OSBPL3 Homo sapiens Q9H4L5
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 OSBPL3 Homo sapiens Q9H4L5
Validated Y2H
32296183
Intra
PRPF18 Q99633 GAS8 Homo sapiens O95995
Y2H Array
32296183
Intra
PRPF18 Q99633 GAS8 Homo sapiens O95995
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 PPIH Homo sapiens O43447
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 PPIH Homo sapiens O43447
Y2H Array
32296183
Intra
PRPF18 Q99633 KRT35 Homo sapiens Q92764
Y2H Array
32296183
Intra
PRPF18 Q99633 KRT35 Homo sapiens Q92764
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 CCDC57 Homo sapiens Q2TAC2-2
Y2H Array
32296183
Intra
PRPF18 Q99633 CCDC57 Homo sapiens Q2TAC2-2
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 HOOK2 Homo sapiens Q96ED9-2
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 HOOK2 Homo sapiens Q96ED9-2
Y2H Array
32296183
Intra
PRPF18 Q99633 FXR1 Homo sapiens P51114-2
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 FXR1 Homo sapiens P51114-2
Y2H Array
32296183
Intra
PRPF18 Q99633 ZNF526 Homo sapiens Q8TF50
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 ZNF526 Homo sapiens Q8TF50
Y2H Array
32296183
Intra
PRPF18 Q99633 IKZF1 Homo sapiens Q13422-7
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 IKZF1 Homo sapiens Q13422-7
Y2H Array
32296183
Intra
PRPF18 Q99633 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
PRPF18 Q99633 AGTRAP Homo sapiens Q6RW13-2
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 AGTRAP Homo sapiens Q6RW13-2
Y2H Array
32296183
Intra
PRPF18 Q99633 UBXN11 Homo sapiens Q5T124-6
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 UBXN11 Homo sapiens Q5T124-6
Y2H Array
32296183
Intra
PRPF18 Q99633 PDE9A Homo sapiens O76083-2
Y2H Array
32296183
Intra
PRPF18 Q99633 PDE9A Homo sapiens O76083-2
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 CBY2 Homo sapiens Q8NA61-2
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 CBY2 Homo sapiens Q8NA61-2
Y2H Array
32296183
Intra
PRPF18 Q99633 CARD9 Homo sapiens Q9H257-2
Y2H Array
32296183
Intra
PRPF18 Q99633 CARD9 Homo sapiens Q9H257-2
Validated Y2H
32296183
Intra
PRPF18 Q99633 CDR2 Homo sapiens Q01850
Y2H Array
32296183
Intra
PRPF18 Q99633 CDR2 Homo sapiens Q01850
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 KCTD7 Homo sapiens Q96MP8-2
Y2H Array
32296183
Intra
PRPF18 Q99633 KCTD7 Homo sapiens Q96MP8-2
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 KRT39 Homo sapiens Q6A163
Y2H Array
32296183
Intra
PRPF18 Q99633 KRT39 Homo sapiens Q6A163
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 SCHIP1 Homo sapiens P0DPB3-4
Y2H Array
32296183
Intra
PRPF18 Q99633 SCHIP1 Homo sapiens P0DPB3-4
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 BICD2 Homo sapiens Q8TD16-2
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 BICD2 Homo sapiens Q8TD16-2
Y2H Array
32296183
Intra
PRPF18 Q99633 LZTS1 Homo sapiens Q9Y250
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 LZTS1 Homo sapiens Q9Y250
Y2H Array
32296183
Intra
PRPF18 Q99633 LZTS1 Homo sapiens Q9Y250
Validated Y2H
32296183
Intra
PRPF18 Q99633 CCDC150 Homo sapiens Q8NCX0-3
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 CCDC150 Homo sapiens Q8NCX0-3
Y2H Array
32296183
Intra
PRPF18 Q99633 PIBF1 Homo sapiens Q4G0R1
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 PIBF1 Homo sapiens Q4G0R1
Y2H Array
32296183
Intra
PRPF18 Q99633 KIFC3 Homo sapiens Q9BVG8-5
Y2H Array
32296183
Intra
PRPF18 Q99633 KIFC3 Homo sapiens Q9BVG8-5
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
Intra
PRPF18 Q99633 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
PRPF18 Q99633 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 TRIM54 Homo sapiens Q9BYV2
Y2H Array
32296183
Intra
PRPF18 Q99633 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
32296183
Intra
PRPF18 Q99633 TSNAX Homo sapiens Q99598
Y2H Array
32296183
Intra
PRPF18 Q99633 TSNAX Homo sapiens Q99598
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 GPBP1 Homo sapiens Q86WP2
Y2H Array
32296183
Intra
PRPF18 Q99633 GPBP1 Homo sapiens Q86WP2
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 EFHC2 Homo sapiens Q5JST6
Y2H Array
32296183
Intra
PRPF18 Q99633 EFHC2 Homo sapiens Q5JST6
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 BLZF1 Homo sapiens Q9H2G9
Validated Y2H
32296183
Intra
PRPF18 Q99633 BLZF1 Homo sapiens Q9H2G9
Y2H Array
32296183
Intra
PRPF18 Q99633 BLZF1 Homo sapiens Q9H2G9
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 GMCL1 Homo sapiens Q96IK5
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 HMBOX1 Homo sapiens Q6NT76
Y2H Array
32296183
Intra
PRPF18 Q99633 HMBOX1 Homo sapiens Q6NT76
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 KANK2 Homo sapiens Q63ZY3
Y2H Array
32296183
Intra
PRPF18 Q99633 KANK2 Homo sapiens Q63ZY3
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 PRKAR1B Homo sapiens P31321
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 PRKAR1B Homo sapiens P31321
Y2H Array
32296183
Intra
PRPF18 Q99633 AP2M1 Homo sapiens Q96CW1
Y2H Array
32296183
Intra
PRPF18 Q99633 AP2M1 Homo sapiens Q96CW1
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 PNMA1 Homo sapiens Q8ND90
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 PNMA1 Homo sapiens Q8ND90
Y2H Array
32296183
Intra
PRPF18 Q99633 MCC Homo sapiens P23508
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 MCC Homo sapiens P23508
Y2H Array
32296183
Intra
PRPF18 Q99633 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
PRPF18 Q99633 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 PFDN5 Homo sapiens Q99471
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 PFDN5 Homo sapiens Q99471
Y2H Array
32296183
Intra
PRPF18 Q99633 CARD10 Homo sapiens Q9BWT7
Validated Y2H
32296183
Intra
PRPF18 Q99633 CARD10 Homo sapiens Q9BWT7
Y2H Array
32296183
Intra
PRPF18 Q99633 CARD10 Homo sapiens Q9BWT7
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 CCNC Homo sapiens P24863
Y2H Array
32296183
Intra
PRPF18 Q99633 CCNC Homo sapiens P24863
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 CSRNP1 Homo sapiens Q96S65
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 CSRNP1 Homo sapiens Q96S65
Y2H Array
32296183
Intra
PRPF18 Q99633 SPRED1 Homo sapiens Q7Z699
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 SPRED1 Homo sapiens Q7Z699
Y2H Array
32296183
Intra
PRPF18 Q99633 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
Intra
PRPF18 Q99633 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra
PRPF18 Q99633 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 FSD2 Homo sapiens A1L4K1
Y2H Array
32296183
Intra
PRPF18 Q99633 FSD2 Homo sapiens A1L4K1
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra
PRPF18 Q99633 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
PRPF18 Q99633 TSNAXIP1 Homo sapiens Q2TAA8
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 TSNAXIP1 Homo sapiens Q2TAA8
Y2H Array
32296183
Intra
PRPF18 Q99633 ASCC2 Homo sapiens Q9H1I8
Validated Y2H
32296183
Intra
PRPF18 Q99633 ASCC2 Homo sapiens Q9H1I8
Y2H Array
32296183
Intra
PRPF18 Q99633 ASCC2 Homo sapiens Q9H1I8
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
PRPF18 Q99633 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 AGR2 Homo sapiens O95994
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 AGR2 Homo sapiens O95994
Y2H Array
32296183
Intra
PRPF18 Q99633 STX11 Homo sapiens O75558
Y2H Array
32296183
Intra
PRPF18 Q99633 STX11 Homo sapiens O75558
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 GRIPAP1 Homo sapiens Q4V328
Y2H Array
32296183
Intra
PRPF18 Q99633 GRIPAP1 Homo sapiens Q4V328
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 TRIM27 Homo sapiens P14373
Y2H Array
32296183
Intra
PRPF18 Q99633 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
PRPF18 Q99633 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
PRPF18 Q99633 RINT1 Homo sapiens Q6NUQ1
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 RINT1 Homo sapiens Q6NUQ1
Y2H Array
32296183
Intra
PRPF18 Q99633 CALCOCO2 Homo sapiens Q13137
Y2H Array
32296183
Intra
PRPF18 Q99633 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra
PRPF18 Q99633 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 DVL3 Homo sapiens Q92997
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 DVL3 Homo sapiens Q92997
Y2H Array
32296183
Intra
PRPF18 Q99633 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 TRIM23 Homo sapiens P36406
Y2H Array
32296183
Intra
PRPF18 Q99633 LDOC1 Homo sapiens O95751
Y2H Array
32296183
Intra
PRPF18 Q99633 LDOC1 Homo sapiens O95751
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 LZTS2 Homo sapiens Q9BRK4
Y2H Array
32296183
Intra
PRPF18 Q99633 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
32296183
Intra
PRPF18 Q99633 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
PRPF18 Q99633 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 BEGAIN Homo sapiens Q9BUH8
Validated Y2H
32296183
Intra
PRPF18 Q99633 BEGAIN Homo sapiens Q9BUH8
Y2H Array
32296183
Intra
PRPF18 Q99633 BEGAIN Homo sapiens Q9BUH8
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 GCC1 Homo sapiens Q96CN9
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 GCC1 Homo sapiens Q96CN9
Y2H Array
32296183
Intra
PRPF18 Q99633 AMOTL2 Homo sapiens Q9Y2J4
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 AMOTL2 Homo sapiens Q9Y2J4
Validated Y2H
32296183
Intra
PRPF18 Q99633 AMOTL2 Homo sapiens Q9Y2J4
Y2H Array
32296183
Intra
PRPF18 Q99633 IKZF3 Homo sapiens Q9UKT9
Y2H Array
32296183
Intra
PRPF18 Q99633 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
32296183
Intra
PRPF18 Q99633 SERTAD1 Homo sapiens Q9UHV2
Validated Y2H
32296183
Intra
PRPF18 Q99633 SERTAD1 Homo sapiens Q9UHV2
Y2H Array
32296183
Intra
PRPF18 Q99633 SERTAD1 Homo sapiens Q9UHV2
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 EVI5L Homo sapiens Q96CN4
Y2H Array
32296183
Intra
PRPF18 Q99633 EVI5L Homo sapiens Q96CN4
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 TXNDC11 Homo sapiens Q6PKC3
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 TXNDC11 Homo sapiens Q6PKC3
Y2H Array
32296183
Intra
PRPF18 Q99633 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
PRPF18 Q99633 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
PRPF18 Q99633 NACC1 Homo sapiens Q96RE7
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 NACC1 Homo sapiens Q96RE7
Y2H Array
32296183
Intra
PRPF18 Q99633 IKBKG Homo sapiens Q9Y6K9
Y2H Array
32296183
Intra
PRPF18 Q99633 IKBKG Homo sapiens Q9Y6K9
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 IKBKG Homo sapiens Q9Y6K9
Validated Y2H
32296183
Intra
PRPF18 Q99633 FANCG Homo sapiens O15287
Y2H Array
32296183
Intra
PRPF18 Q99633 FANCG Homo sapiens O15287
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 TTC23 Homo sapiens Q5W5X9-3
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 TTC23 Homo sapiens Q5W5X9-3
Y2H Array
32296183
Intra
PRPF18 Q99633 ZNF639 Homo sapiens Q9UID6
Y2H Array
32296183
Intra
PRPF18 Q99633 ZNF639 Homo sapiens Q9UID6
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 ZNF639 Homo sapiens Q9UID6
Validated Y2H
32296183
Intra
PRPF18 Q99633 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra
PRPF18 Q99633 PLEKHG4 Homo sapiens Q58EX7
Y2H Prey Pooling
32296183
Intra
PRPF18 Q99633 PLEKHG4 Homo sapiens Q58EX7
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11206 PRPF19 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11216 PRPF8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21700 Prpf8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28218 Prpf8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown