ZNF639 - zinc finger protein 639 Gene

Also Known as ZASC1; ANC-2H01; ANC_2H01

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 51193

Summary

This gene encodes a member of the Kruppel-like zinc finger family of proteins. Amplification and overexpression of this gene have been observed in esophageal Squamous Cell Carcinoma. The encoded protein has been shown to bind DNA in a sequence-specific manner and may regulate HIV-1 gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Ubiquitous expression in thyroid (RPKM 9.3), bone marrow (RPKM 8.6) and 25 other tissues.

ZNF639 Products (10)

mRNA Protein Name
NM_001303425.2 NP_001290354.1 zinc finger protein 639
NM_001303426.2 NP_001290355.1 zinc finger protein 639
NM_001375800.1 NP_001362729.1 zinc finger protein 639
NM_001375802.1 NP_001362731.1 zinc finger protein 639
NM_001375803.1 NP_001362732.1 zinc finger protein 639
NM_001375804.1 NP_001362733.1 zinc finger protein 639
NM_001375805.1 NP_001362734.1 zinc finger protein 639
NM_001375806.1 NP_001362735.1 zinc finger protein 639
NM_001375807.1 NP_001362736.1 zinc finger protein 639
NM_016331.3 NP_057415.1 zinc finger protein 639

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
20484494 GOA
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
16182284 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
20484494 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16182284 GOA
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
20484494 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in negative regulation by host of viral transcription IMP
IMP: Inferred from mutant phenotype
20484494 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16182284 GOA
involved in positive regulation by host of viral transcription IMP
IMP: Inferred from mutant phenotype
20484494 GOA
involved in positive regulation of cell growth IMP
IMP: Inferred from mutant phenotype
14522885 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20484494 GOA
involved in symbiont entry into host cell IDA
IDA: Inferred from direct assay
20484494 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in nucleus IDA
IDA: Inferred from direct assay
14522885 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF639 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
ZNF639 Q9UID6 PNKP Homo sapiens Q96T60
Y2H Prey Pooling
25416956
Intra
ZNF639 Q9UID6 PNKP Homo sapiens Q96T60
Y2H Array
25416956
Intra
ZNF639 Q9UID6 CTNNA2 Homo sapiens P26232
Anti Tag CoIP
16182284
Intra
ZNF639 Q9UID6 CTNNA2 Homo sapiens P26232
IF
16182284
Intra
ZNF639 Q9UID6 CTNNA2 Homo sapiens P26232
Y2H
16182284
Intra
ZNF639 Q9UID6 CTNNA2 Homo sapiens P26232
Anti Bait CoIP
16182284
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS16159 ZNF609 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16161 ZNF638 Human Pre-designed siRNA Set A Pre-designed Set / Unkown