FANCG - FA complementation group G Gene

Also Known as FAG; XRCC9

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2189

About FANCG

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:35,073,839-35,079,942 (from NCBI)

This gene has 22 transcripts (splice variants), 185 orthologues and is associated with 62 phenotypes. Ubiquitous expression in bone marrow (RPKM 5.8), testis (RPKM 5.2) and 25 other tissues.

Summary

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G. [provided by RefSeq, Jul 2008]

FANCG Products (1)

mRNA	Protein	Name
NM_004629.2	NP_004620.1	Fanconi anemia group G protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10627486	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in mitochondrion organization	IMP IMP: Inferred from mutant phenotype	17060495	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of Fanconi anaemia nuclear complex	IDA IDA: Inferred from direct assay	20347428	GOA
located in chromatin	IDA IDA: Inferred from direct assay	22343915	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	17060495	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FANCG Protein Structure

TPR_1

0
100
200
300
400
500
622 a.a.

Protein Preferred Names	Protein Names
Fanconi anemia group G protein	DNA repair protein XRCC9

FANCG Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	FANCG	O15287	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	32296183
Intra	FANCG	O15287	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	FANCG	O15287	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	FANCG	O15287	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	FANCG	O15287	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	FANCG	O15287	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	FANCG	O15287	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	FANCG	O15287	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	FANCG	O15287	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	FANCG	O15287	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	FANCG	O15287	TCEANC	Homo sapiens	Q8N8B7-2	Validated Y2H	32296183
Intra	FANCG	O15287	TPRX1	Homo sapiens	Q8N7U7-2	Validated Y2H	32296183
Intra	FANCG	O15287	GLE1	Homo sapiens	Q53GS7	Validated Y2H	32814053
Intra	FANCG	O15287	GLE1	Homo sapiens	Q53GS7	Y2H Pooling	32814053
Intra	FANCG	O15287	GLE1	Homo sapiens	Q53GS7	Y2H Array	32814053
Intra	FANCG	O15287	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	FANCG	O15287	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	FANCG	O15287	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	FANCG	O15287	PRPF18	Homo sapiens	Q99633	Validated Y2H	32296183
Intra	FANCG	O15287	SPTAN1	Homo sapiens	Q13813	Anti Bait CoIP	19102630
Intra	FANCG	O15287	SPTAN1	Homo sapiens	Q13813	Y2H	19102630
Intra	FANCG	O15287	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	FANCG	O15287	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	FANCG	O15287	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	FANCG	O15287	VIM	Homo sapiens	P08670	Validated Y2H	32814053
Intra	FANCG	O15287	VIM	Homo sapiens	P08670	Y2H Pooling	32814053
Intra	FANCG	O15287	VIM	Homo sapiens	P08670	Y2H Array	32814053
Intra	FANCG	O15287	SUOX	Homo sapiens	P51687	Validated Y2H	32296183
Intra	FANCG	O15287	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	FANCG	O15287	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	FANCG	O15287	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	FANCG	O15287	NDUFV2	Homo sapiens	P19404	Validated Y2H	32814053
Intra	FANCG	O15287	NDUFV2	Homo sapiens	P19404	Y2H Array	32814053
Intra	FANCG	O15287	NDUFV2	Homo sapiens	P19404	Y2H Pooling	32814053
Intra	FANCG	O15287	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	FANCG	O15287	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
Intra	FANCG	O15287	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053
Intra	FANCG	O15287	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	FANCG	O15287	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	FANCG	O15287	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	FANCG	O15287	ZNF329	Homo sapiens	Q86UD4	Validated Y2H	32296183
Intra	FANCG	O15287	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	FANCG	O15287	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	FANCG	O15287	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	FANCG	O15287	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	FANCG	O15287	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	FANCG	O15287	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	FANCG	O15287	FANCA	Homo sapiens	O15360	Anti Tag CoIP	33961781
Intra	FANCG	O15287	FANCA	Homo sapiens	O15360	Lumier	37398436
Intra	FANCG	O15287	FANCA	Homo sapiens	O15360	CoIP	11063725
Intra	FANCG	O15287	FANCA	Homo sapiens	O15360	Anti Tag CoIP	28514442
Intra	FANCG	O15287	FANCA	Homo sapiens	O15360	Y2H	12649160
Intra	FANCG	O15287	FANCA	Homo sapiens	O15360	BRET	37398436
Intra	FANCG	O15287	FANCF	Homo sapiens	Q9NPI8	Y2H	12649160
Intra	FANCG	O15287	FANCF	Homo sapiens	Q9NPI8	CoIP	11063725
Intra	FANCG	O15287	ATXN3	Homo sapiens	P54252	Y2H Array	32814053
Intra	FANCG	O15287	ATXN3	Homo sapiens	P54252	Y2H Pooling	32814053
Intra	FANCG	O15287	ATXN3	Homo sapiens	P54252	Validated Y2H	32814053
Cross	FANCG	O15287	tax	Human T-cell leukemia virus 1	P14079	MAPPIT	22458338

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Fanconi Anemia, Complementation Group G	Fanconi Anemia Complementation Group G FANCG
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Fanconi Anemia, Complementation Group L	Fanconi Anemia Complementation Group L FANCL
Pituitary Stalk Interruption Syndrome	Ectopic Neurohypophysis Psis
Fanconi Anemia, Complementation Group E	Fanconi Anemia Complementation Group E FANCE Face Faces Syndrome
Fanconi Anemia, Complementation Group F	Fanconi Anemia Complementation Group F FANCF
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Fanconi Anemia, Complementation Group D1	Fanconi Anemia Complementation Group D1 FANCD1 Fad1 Inherited Cancer-Predisposing Syndrome Due To Biallelic Brca2 Mutations
Fanconi Anemia, Complementation Group B	Fanconi Anemia Complementation Group B FANCB Facb Fa2 Fanconi Pancytopenia Type 2 Fanconi Pancytopenia, Type 2
Pancytopenia
Fanconi Anemia, Complementation Group U	Fanconi Anemia Complementation Group U FANCU
Bloom Syndrome	BLM Bs Bls Bloom-Torre-Machacek Syndrome Microcephaly, Growth Restriction, And Increased Sister Chromatid Exchange 1 Mgrisce1 Congenital Telangiectatic Erythema Congenital Telangiectatic Erythema Syndrome Growth Deficiency, Sun-Sensitive, Telangiectatic, Hypo And Hyperpigmented Skin, Predisposition To Malignancy And Chromosomal Instability Bloom'S Syndrome Bsyn
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Fanconi Anemia, Complementation Group T	Fanconi Anemia Complementation Group T FANCT
Peliosis Hepatis	Hepatic Peliosis Telangiectasis Of Liver Angiomatosis Of Liver Ph - [Peliosis Hepatis] Hepatic Angiomatosis
Physical Disorder	Physical Illness
Fanconi Anemia, Complementation Group D2	Fanconi Anemia Complementation Group D2 FANCD2 Fad2 Fa4 Fancd Fanconi Pancytopenia Type 4 Fanconi Anemia, Complementation Group D Fanconi Pancytopenia, Type 4 Facd Fanconi Anemia Complementation Group D
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Aplastic Anemia	Aplastic Anemia, Susceptibility To Anemia Aplastic Idiopathic Aplastic Anemia Secondary Aplastic Anemia Idiopathic Bone Marrow Failure Aplastic Anemia Idiopathic AA Anemia, Aplastic Aplastic Anemia, Idiopathic Erythroid Aplasia Aa - [Aplastic Anaemia] Haematopoietic Aplasia Aleukia Haemorrhagica Anaemia Due To Decreased Red Cell Production Aplasia Bone Marrow Aplastic Bone Marrow Hypoplastic Anaemia Nos Myeloid Bone Marrow Aplasia Pancytopenia Panhaematopenia Hypoproliferative Anaemia Medullary Hypoplasia Red Blood Cells Hypoplastic Anaemia Panmyelophthisis Panhemocytopenia Refractive Hypoproliferative Anaemia Toxic Anaemia Toxic Aplastic Anaemia Aplastic Anaemia Due To Toxic Cause Idiopathic Aplastic Anaemia Nos
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Shwachman-Diamond Syndrome 1	Shwachman-Diamond Syndrome Shwachman Syndrome Shwachman-Bodian-Diamond Syndrome Sds Pancreatic Insufficiency And Bone Marrow Dysfunction Shwachman-Bodian Syndrome SDS1 Lipomatosis Of Pancreas, Congenital Congenital Lipomatosis Of Pancreas Shwachman-Diamond Type Metaphyseal Dysplasia Metaphyseal Chondrodysplasia, Shwachman Type Shwachman-Diamond-Oski Syndrome
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Dyskeratosis Congenita	Dyskeratosis Congenita Autosomal Dominant Dc Dkc Zinsser-Engman-Cole Syndrome Dyskeratosis Congenita, Autosomal Dominant Autosomal Dominant Dyskeratosis Congenita Dkca Dyskeratosis Congenita Scoggins Type Zinsser-Cole-Engman Syndrome X-Linked Dyskeratosis Congenita Hoyeraal-Hreidarsson Syndrome
Seckel Syndrome	Microcephalic Primordial Dwarfism Bird-Headed Dwarfism Harper'S Syndrome Virchow-Seckel Dwarfism Nanocephalic Dwarfism Sckl Seckel-Type Dwarfism
Lynch Syndrome	Hereditary Nonpolyposis Colon Cancer Hereditary Nonpolyposis Colorectal Cancer Hereditary Nonpolyposis Colorectal Carcinoma Hereditary Nonpolyposis Colorectal Neoplasms Familial Nonpolyposis Colon Cancer Hnpcc Coca 1 Hereditary Defective Mismatch Repair Syndrome Hereditary Non-Polyposis Colon Cancer Hereditary Non-Polyposis Colon Cancer Syndrome Hereditary Non-Polyposis Colorectal Cancer Hereditary Non-Polyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colon Cancer Syndrome Hereditary Nonpolyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colorectal Neoplasm Hnpcc - Hereditary Nonpolyposis Colon Cancer Cancer Family Syndrome Familial Nonpolyposis Colorectal Cancer Colon Cancer, Familial Nonpolyposis Colorectal Neoplasms, Hereditary Nonpolyposis Cancer, Colorectal, Nonpolyposis, Hereditary Colorectal Cancer, Hereditary Nonpolyposis, Type 1
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS04738	FANCG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FANCG	VGNC	VGNC:72612
Felis catus	FANCG	VGNC	VGNC:102925
Canis familiaris	FANCG	VGNC	VGNC:40722
Mus musculus	FANCG	MGD	MGI:1926471
Rattus norvegicus	FANCG	RGD	RGD:1587477
Bos taurus	FANCG	VGNC	VGNC:28858
Others	FANCG	NCBI