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MCC - MCC regulator of WNT signaling pathway Gene

Also Known as MCC1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4163

About MCC

Cytogenetic location: 5q22.2 Genomic coordinates (GRCh38): 5:113,022,106-113,488,453 (from NCBI)

This gene has 10 transcripts (splice variants), 160 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in ovary (RPKM 18.3), skin (RPKM 6.6) and 21 other tissues.

Summary

This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

MCC Products (2)

mRNA	Protein	Name
NM_001085377.2	NP_001078846.2	colorectal mutant cancer protein isoform 1
NM_002387.3	NP_002378.2	colorectal mutant cancer protein isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14743216	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in establishment of protein localization	IDA IDA: Inferred from direct assay	18591935	GOA
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	18591935	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	24824780	GOA
involved in negative regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	19555689	GOA
involved in negative regulation of epithelial cell proliferation	IDA IDA: Inferred from direct assay	18591935	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18591935	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18591935	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19555689	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MCC Protein Structure

MCC-bdg_PDZ

0
200
400
600
829 a.a.

Protein Preferred Names	Protein Names
colorectal mutant cancer protein	MCC, WNT signaling pathway regulator

MCC Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MCC	P23508	ZNF543	Homo sapiens	Q08ER8	Validated Y2H	32296183
Intra	MCC	P23508	ZNF792	Homo sapiens	Q3KQV3	Validated Y2H	32296183
Intra	MCC	P23508	CFAP58	Homo sapiens	Q5T655	Validated Y2H	32296183
Intra	MCC	P23508	SYT6	Homo sapiens	Q5T7P8-2	Validated Y2H	32296183
Intra	MCC	P23508	POLL	Homo sapiens	Q9UGP5-2	Validated Y2H	32296183
Intra	MCC	P23508	PNKP	Homo sapiens	Q96T60	Validated Y2H	32296183
Intra	MCC	P23508	ZNF497	Homo sapiens	Q6ZNH5	Validated Y2H	32296183
Intra	MCC	P23508	TSHZ2	Homo sapiens	Q9NRE2	Validated Y2H	32296183
Intra	MCC	P23508	CCDC146	Homo sapiens	Q8IYE0	Validated Y2H	32296183
Intra	MCC	P23508	CEP57L1	Homo sapiens	Q8IYX8	Validated Y2H	32296183
Intra	MCC	P23508	UTP14C	Homo sapiens	Q5TAP6	Validated Y2H	32296183
Intra	MCC	P23508	TCEANC	Homo sapiens	Q8N8B7-2	Validated Y2H	32296183
Intra	MCC	P23508	ZNF438	Homo sapiens	Q7Z4V0	Validated Y2H	32296183
Intra	MCC	P23508	ZNF648	Homo sapiens	Q5T619	Validated Y2H	32296183
Intra	MCC	P23508	ESRRG	Homo sapiens	P62508-3	Validated Y2H	32296183
Intra	MCC	P23508	CCDC112	Homo sapiens	Q8NEF3-2	Validated Y2H	32296183
Intra	MCC	P23508	RASAL2	Homo sapiens	Q9UJF2-2	Validated Y2H	32296183
Intra	MCC	P23508	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	MCC	P23508	MGC50722	Homo sapiens	Q8IVT4	Validated Y2H	32296183
Intra	MCC	P23508	RCOR3	Homo sapiens	Q9P2K3-2	Validated Y2H	32296183
Intra	MCC	P23508	TRMT2A	Homo sapiens	Q8IZ69	Validated Y2H	32296183
Intra	MCC	P23508	PRPF18	Homo sapiens	Q99633	Validated Y2H	32296183
Intra	MCC	P23508	LRRC45	Homo sapiens	Q96CN5	Validated Y2H	32296183
Intra	MCC	P23508	SLTM	Homo sapiens	Q9NWH9	Validated Y2H	32296183
Intra	MCC	P23508	GTF2E2	Homo sapiens	P29084	Y2H Array	21988832
Intra	MCC	P23508	GTF2E2	Homo sapiens	P29084	Anti Tag CoIP	21988832
Intra	MCC	P23508	NFKBIB	Homo sapiens	Q15653	Anti Tag CoIP	33961781
Intra	MCC	P23508	NFKBIB	Homo sapiens	Q15653	TAP	14743216
Intra	MCC	P23508	SCRIB	Homo sapiens	Q14160	Y2H	19555689
Intra	MCC	P23508	SCRIB	Homo sapiens	Q14160	Pull Down	19555689
Intra	MCC	P23508	SCRIB	Homo sapiens	Q14160	Anti Bait CoIP	19555689
Intra	MCC	P23508	TXLNA	Homo sapiens	P40222	Validated Y2H	32296183
Intra	MCC	P23508	CEP95	Homo sapiens	Q96GE4	Validated Y2H	32296183
Intra	MCC	P23508	CDKL3	Homo sapiens	Q8IVW4	Validated Y2H	32296183
Intra	MCC	P23508	KAT5	Homo sapiens	Q92993	Validated Y2H	32296183
Intra	MCC	P23508	NEK2	Homo sapiens	P51955	Anti Tag CoIP	33961781
Intra	MCC	P23508	TCEA2	Homo sapiens	Q15560	Validated Y2H	32296183
Intra	MCC	P23508	CBX8	Homo sapiens	Q9HC52	Validated Y2H	32296183
Intra	MCC	P23508	C8orf33	Homo sapiens	Q9H7E9	Validated Y2H	32296183
Intra	MCC	P23508	NOL12	Homo sapiens	Q9UGY1	Validated Y2H	32296183
Intra	MCC	P23508	FAM161A	Homo sapiens	Q3B820	Validated Y2H	32296183
Intra	MCC	P23508	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	32296183
Intra	MCC	P23508	CCDC185	Homo sapiens	Q8N715	Validated Y2H	32296183
Intra	MCC	P23508	THAP7	Homo sapiens	Q9BT49	Validated Y2H	32296183
Intra	MCC	P23508	ELOA	Homo sapiens	Q14241	Validated Y2H	32296183
Intra	MCC	P23508	SYT17	Homo sapiens	Q9BSW7	Validated Y2H	32296183
Intra	MCC	P23508	IMP3	Homo sapiens	Q9NV31	Validated Y2H	32296183
Intra	MCC	P23508	CSNK1E	Homo sapiens	P49674	Anti Bait CoIP	17353931
Intra	MCC	P23508	CSNK1E	Homo sapiens	P49674	Y2H	21900206
Intra	MCC	P23508	CSNK1E	Homo sapiens	P49674	Anti Tag CoIP	33961781
Intra	MCC	P23508	C8orf48	Homo sapiens	Q96LL4	Validated Y2H	32296183
Intra	MCC	P23508	DNAAF4	Homo sapiens	Q8WXU2-2	Validated Y2H	32296183
Intra	MCC	P23508	MAGEE1	Homo sapiens	Q9HCI5	Anti Tag CoIP	33961781
Intra	MCC	P23508	MAGEE1	Homo sapiens	Q9HCI5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

MCC Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810028	MCC Antibody (YA9372)	WB, ICC/IF, IF-Tissue, IP, ELISA	human, mouse, rat

Related Diseases

Diseases	Alias
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Familial Adenomatous Polyposis	Adenomatous Polyposis Coli Fap Familial Polyposis Coli Familial Multiple Polyposis Syndrome Adenomatous Polyposis Of The Colon Familial Intestinal Polyposis Fpc Familial Adenomatous Polyposis Of The Colon Familial Multiple Polyposis Familial Polyposis Of The Colon Hereditary Polyposis Coli Polyposis, Adenomatous Intestinal Adenomatous Familial Polyposis Adenomatous Familial Polyposis Syndrome Myh-Associated Polyposis Colorectal Adenomatous Polyposis Adenomatous Polyposis, Familial Mutyh-Associate Polyposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-100428	Netoglitazone	Modulator	99.92%	Phase 2
HY-100298	Caldaret	Inhibitor	98.35%	Phase 2
HY-132251	MCC		95.0%	Phase 2
HY-100428R	Netoglitazone (Standard)	Modulator	/	Phase 2
HY-185483	AMG-172	Inhibitor	/	Phase 1
HY-119306	MCC-134	Modulator	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12815	MCC950	Inhibitor	99.78%	Unkown
HY-12815A	MCC950 sodium	Inhibitor	99.75%	Unkown
HY-101982	Lys-SMCC-DM1		99.25%	Unkown
HY-132250	MCC-DM1		99.52%	Unkown
HY-174279	MCC-AAQ-Exa		95.33%	Unkown
HY-137245	Emlenoflast	Inhibitor	99.30%	Unkown
HY-101982A	(Rac)-Lys-SMCC-DM1		98.58%	Unkown
HY-137245A	Emlenoflast sodium	Inhibitor	98.31%	Unkown
HY-119691	Alamifovir	Inhibitor	95.0%	Unkown
HY-128959	MCC-Modified Daunorubicinol		/	Unkown
HY-148528	SC-VC-PAB-N-Me-L-Ala-Maytansinol		98.66%	Unkown
HY-101266A	Milademetan tosylate	MDM2 Inhibitor	/	Unkown
HY-141143	MC(C5)-Val-Cit		/	Unkown
HY-14936	Sofigatran	Inhibitor	/	Unkown
HY-163982	FOXJ1 agonist 1		/	Unkown
HY-P1735	Moth Cytochrome C (MCC) (88-103)		/	Unkown
HY-RS08217	MCC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W162436	MCC1019		/	Unkown
HY-W800786	16:0 PE MCC		/	Unkown
HY-W800787	18:1 PE MCC		/	Unkown
HY-RS17089	Mcc Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23533	Mcc Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W190944	DM1-MCC-PEG3-Biotin		/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991661	AMG-172 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MCC	VGNC	VGNC:68207
Canis familiaris	MCC	VGNC	VGNC:54780
Mus musculus	MCC	MGD	MGI:96930
Macaca mulatta	MCC	VGNC	VGNC:74675
Rattus norvegicus	MCC	RGD	RGD:1561988
Bos taurus	MCC	VGNC	VGNC:54784
Others	MCC	NCBI