Milademetan tosylate
Based on 5 publication(s) in Google Scholar
Milademetan tosylate is the tosylate salt form of Milademetan (HY-101266). Milademetan tosylate is an orally active inhibitor for MDM2. Milademetan tosylate arrests the cell cycle at G1 pahse, induces the apoptosis Milademetan tosylate restores the p53 activity by targeting the p53-MDM2 interaction, and exhibits anticancer activity against Merkel cell carcinoma (MCC).
For research use only. We do not sell to patients.
- CAS No.: 1398569-75-9
- Formula: C37H42Cl2FN5O7S
- Molecular Weight:790.73
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Milademetan tosylate
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Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1398569-75-9
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Molecular Weight 790.73
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Formula C37H42Cl2FN5O7S
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SMILES
O=C(NC1=CC(Cl)=CC=C21)[C@]32C4(CCC(C)(C)CC4)N[C@@H](C(N[C@@H]5CC[C@@H](C(N)=O)OC5)=O)[C@@H]3C6=CC=NC(Cl)=C6F.O=S(C7=CC=C(C)C=C7)(O)=O
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Synonyms
DS-3032 tosylate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (5)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jan;637(8047):955-964. PMID: 39695225 -
Int J Mol Sci
Pharmacological Inhibition of MDM2 Induces Apoptosis in p53-Mutated Triple-Negative Breast Cancer. [Abstract]2025 Jan 26;26(3):1078. PMID: 39940844 -
Biomedicines
High-Throughput Drug Library Screening in Primary KMT2A-Rearranged Infant ALL Cells Favors the Identification of Drug Candidates That Activate P53 Signaling. [Abstract]2022 Mar 10;10(3):638. PMID: 35327440 -
bioRxiv
2024 Nov 20:2024.10.24.620074. PMID: 39484513 -
bioRxiv
2023 Jun 26:2023.06.25.546239. PMID: 37425909
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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