AMG-172
AMG-172 is an antibody-drug conjugate (ADC) composed of a fully human IgG1 monoclonal anti-CD27L antibody conjugated to DM1 (HY-19792) via the non-cleavable linker MCC. AMG-172 releases the intracellular active component Lysine-MCC-DM through catabolism. Lysine-MCC-DM inhibits the assembly and disassembly dynamics of Microtubule and induces cell arrest at metaphase. AMG-172 can be used for research on relapsed/refractory clear cell renal cell carcinoma.
For research use only. We do not sell to patients.
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
SMILES
[AMG-172]
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AMG-172 Related Classifications
HY-185483 Related Classifications
Powered by Bioz
- AMG-172
- AMG172
- AMG 172
- Antibody-Drug Conjugates (ADCs)
- Transmembrane Glycoprotein
- Microtubule/Tubulin
- IgG1 monoclonal anti-CD27L antibody
- metaphase arrest
- MCC
- relapsed/refractory clear cell renal cell carcinoma
- antibody-drug conjugate
- microtubule assembly/disassembly dynamics
- CD27L-expressing cells
- maytansinoid cytotoxin DM1
- Inhibitor
- inhibitor
- inhibit