2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. MCC

MCC is non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as MCC-DM1.

For research use only. We do not sell to patients.

MCC

MCC Chemical Structure

CAS No. : 104676-09-7

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Based on 1 publication(s) in Google Scholar

MCC Related Antibodies

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Description

MCC is non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as MCC-DM1[1].

In Vitro

Antibody-drug conjugates (ADCs) are potent cytotoxic drugs linked to antibodies through chemical linkers, and allow specific targeting of drugs to neoplastic cells. Anti-CD22-MCC-DM1 is broadly effective in vitro against multiple NHL cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MCC Related Antibodies
Clinical Trial
Molecular Weight

236.27

Formula

C12H16N2O3
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

O=C(C=CC1=O)N1CC2CCC(C(N)=O)CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (423.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2324 mL 21.1621 mL 42.3243 mL
5 mM 0.8465 mL 4.2324 mL 8.4649 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.2324 mL 21.1621 mL 42.3243 mL 105.8107 mL
5 mM 0.8465 mL 4.2324 mL 8.4649 mL 21.1621 mL
10 mM 0.4232 mL 2.1162 mL 4.2324 mL 10.5811 mL
15 mM 0.2822 mL 1.4108 mL 2.8216 mL 7.0540 mL
20 mM 0.2116 mL 1.0581 mL 2.1162 mL 5.2905 mL
25 mM 0.1693 mL 0.8465 mL 1.6930 mL 4.2324 mL
30 mM 0.1411 mL 0.7054 mL 1.4108 mL 3.5270 mL
40 mM 0.1058 mL 0.5291 mL 1.0581 mL 2.6453 mL
50 mM 0.0846 mL 0.4232 mL 0.8465 mL 2.1162 mL
60 mM 0.0705 mL 0.3527 mL 0.7054 mL 1.7635 mL
80 mM 0.0529 mL 0.2645 mL 0.5291 mL 1.3226 mL
100 mM 0.0423 mL 0.2116 mL 0.4232 mL 1.0581 mL
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MCC Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MCC104676-09-7ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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