country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

TRMT2A - tRNA methyltransferase 2 homolog A Gene

Also Known as HTF9C

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27037

About TRMT2A

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:20,111,875-20,117,226 (from NCBI)

This gene has 18 transcripts (splice variants), 201 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 11.1), testis (RPKM 10.2) and 25 other tissues.

Summary

The protein encoded by this gene is of unknown function. However, it is orthologous to the mouse Trmt2a gene and contains an RNA methyltransferase domain. Expression of this gene varies during the cell cycle, with aberrant expression being a possible biomarker in certain breast cancers. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

TRMT2A Products (4)

mRNA	Protein	Name
NM_001257994.2	NP_001244923.1	tRNA (uracil-5-)-methyltransferase homolog A isoform b
NM_001331039.2	NP_001317968.1	tRNA (uracil-5-)-methyltransferase homolog A isoform c
NM_022727.6	NP_073564.3	tRNA (uracil-5-)-methyltransferase homolog A isoform a
NM_182984.5	NP_892029.2	tRNA (uracil-5-)-methyltransferase homolog A isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables C-methyltransferase activity	IDA IDA: Inferred from direct assay	34123281	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent	IDA IDA: Inferred from direct assay	31361898	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRMT2A Protein Structure

tRNA_U5-meth_tr

0
100
200
300
400
500
625 a.a.

Protein Preferred Names	Protein Names
tRNA (uracil-5-)-methyltransferase homolog A	TRM2 tRNA methyltransferase 2 homolog A

TRMT2A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRMT2A	Q8IZ69	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	TRMT2A	Q8IZ69	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	TRMT2A	Q8IZ69	ZNF837	Homo sapiens	Q96EG3	Y2H Prey Pooling	32296183
Intra	TRMT2A	Q8IZ69	ZNF837	Homo sapiens	Q96EG3	Y2H Array	32296183
Intra	TRMT2A	Q8IZ69	ZNF837	Homo sapiens	Q96EG3	Validated Y2H	32296183
Intra	TRMT2A	Q8IZ69	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	TRMT2A	Q8IZ69	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	TRMT2A	Q8IZ69	MCC	Homo sapiens	P23508	Y2H Array	32296183
Intra	TRMT2A	Q8IZ69	MCC	Homo sapiens	P23508	Y2H Prey Pooling	32296183
Intra	TRMT2A	Q8IZ69	MESD	Homo sapiens	Q14696	Y2H Prey Pooling	32296183
Intra	TRMT2A	Q8IZ69	MESD	Homo sapiens	Q14696	Y2H Array	32296183
Intra	TRMT2A	Q8IZ69	APPBP2	Homo sapiens	Q92624	Y2H Array	32296183
Intra	TRMT2A	Q8IZ69	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	32296183
Intra	TRMT2A	Q8IZ69	APPBP2	Homo sapiens	Q92624	Validated Y2H	32296183
Intra	TRMT2A	Q8IZ69	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	TRMT2A	Q8IZ69	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	TRMT2A	Q8IZ69	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

TRMT2A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81918	TRMT2A Antibody (YA1663)	WB, IHC-F, IHC-P, ICC/IF	Human
HY-P81918A	TRMT2A Antibody (YA1663)(PBS only)	WB, IHC-F, IHC-P, ICC/IF	Human

Related Diseases

Diseases	Alias
Breast Mucinous Carcinoma	Mucinous Carcinoma Of Breast Invasive Mucinous Breast Carcinoma
Velocardiofacial Syndrome	Shprintzen Syndrome VCFS Chromosome 22q11.2 Deletion Syndrome Vcf Syndrome Shprintzen Vcf Syndrome Vcf-Velocardiofacial Syndrome Velo-Cardio-Facial Syndrome Digeorge Syndrome 22q11 Deletion Syndrome Conotruncal Anomaly Face Syndrome
Chromosome 22q11.2 Deletion Syndrome, Distal	22q11.2 Deletion Syndrome Autosomal Dominant Opitz G/Bbb Syndrome Catch22 Cayler Cardiofacial Syndrome Conotruncal Anomaly Face Syndrome Digeorge Syndrome Sedlackova Syndrome Shprintzen Syndrome Velocardiofacial Syndrome 22q11.2 Distal Deletion Syndrome Distal 22q11.2 Microdeletion Syndrome 22q11.2ds Vcfs Velo-Cardio-Facial Syndrome Distal Chromosome 22q11.2 Deletion Syndrome Chromosome 22q11.2 Deletion Syndrome Distal Chromosome 22q11.2 Deletion Syndrome Deletion 22q11.2 Syndrome 22q11ds Catch 22 Digeorge Sequence Microdeletion 22q11.2 Monosomy 22q11 Takao Syndrome Distal Del(22)(Q11.2) Distal Monosomy 22q11.2 Catch 22 Syndrome Chromosome Deletion Syndrome 22q11.2, Distal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15091	TRMT2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TRMT2A	MGD	MGI:96270
Felis catus	TRMT2A	VGNC	VGNC:66571
Canis familiaris	TRMT2A	VGNC	VGNC:47858
Macaca mulatta	TRMT2A	VGNC	VGNC:79463
Rattus norvegicus	TRMT2A	RGD	RGD:1310418
Bos taurus	TRMT2A	VGNC	VGNC:36372
Others	TRMT2A	NCBI