2. Gene
  3. GTF2E2 - general transcription factor IIE subunit 2 Gene

GTF2E2 - general transcription factor IIE subunit 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FE; TTD6; TF2E2; TFIIE-B

Gene ID: 2961 | Gene type: protein coding

About GTF2E2

Cytogenetic location: 8p12 Genomic coordinates (GRCh38): 8:30,578,318-30,658,236 (from NCBI)

This gene has 5 transcripts (splice variants), 205 orthologues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 12.1), lymph node (RPKM 9.3) and 25 other tissues.

Summary

The general transcription factor IIE (TFIIE) is part of the RNA polymerase II transcription initiation complex, recruiting TFIIH and being essential for promoter clearance by RNA polymerase II. TFIIE is a heterodimer (and sometimes heterotetramer) of alpha and beta subunits. The protein encoded by this gene represents the beta subunit of TFIIE. [provided by RefSeq, Jan 2017]

GTF2E2 Products(2)

mRNA Protein Name
NM_001348353.1 NP_001335282.1 transcription initiation factor IIE subunit beta isoform 2
NM_002095.6 NP_002086.1 transcription initiation factor IIE subunit beta isoform 1

GTF2E2 Protein Structure

TFIIE_beta

TFIIE_beta: TFIIE beta subunit core domain (73 - 145)

  • 0
  • 100
  • 200
  • 291 a.a.
Protein Preferred Names Protein Names

transcription initiation factor IIE subunit beta

TFIIE beta subunit

Related Diseases

Diseases Alias
Trichothiodystrophy 6, Nonphotosensitive

TTD6

Nonphotosensitive Trichothiodystrophy 6

Trichothiodystrophy 6, Non-Photosensitive
Trichothiodystrophy

Ttd

Amish Brittle Hair Syndrome

Bids Syndrome

Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome

Ibids

Pibids

Trichothiodystrophy Syndromes
Ichthyosis

Ichthyoses

Non-Syndromic Ichthyosis

Congenital Ichthyosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05895 GTF2E2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GTF2E2 VGNC VGNC:41545
Mus musculus GTF2E2 MGD MGI:1915403
Rattus norvegicus GTF2E2 RGD RGD:1310134
Bos taurus GTF2E2 VGNC VGNC:29694
Felis catus GTF2E2 VGNC VGNC:67496
Macaca mulatta GTF2E2 VGNC VGNC:73308