GTF2E2 - general transcription factor IIE subunit 2 Gene

Also Known as FE; TTD6; TF2E2; TFIIE-B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2961

About GTF2E2

Cytogenetic location: 8p12 Genomic coordinates (GRCh38): 8:30,578,318-30,658,236 (from NCBI)

This gene has 5 transcripts (splice variants), 205 orthologues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 12.1), lymph node (RPKM 9.3) and 25 other tissues.

Summary

The general transcription factor IIE (TFIIE) is part of the RNA polymerase II transcription initiation complex, recruiting TFIIH and being essential for promoter clearance by RNA polymerase II. TFIIE is a heterodimer (and sometimes heterotetramer) of alpha and beta subunits. The protein encoded by this gene represents the beta subunit of TFIIE. [provided by RefSeq, Jan 2017]

GTF2E2 Products (2)

mRNA Protein Name
NM_001348353.1 NP_001335282.1 transcription initiation factor IIE subunit beta isoform 2
NM_002095.6 NP_002086.1 transcription initiation factor IIE subunit beta isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables RNA polymerase II general transcription initiation factor activity IDA
IDA: Inferred from direct assay
27193682 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7926747 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
27193682 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of transcription factor TFIID complex IDA
IDA: Inferred from direct assay
27193682 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GTF2E2 Protein Structure

TFIIE_beta

TFIIE_beta: TFIIE beta subunit core domain (73 - 145)

  • 0
  • 100
  • 200
  • 291 a.a.
Protein Preferred Names Protein Names

transcription initiation factor IIE subunit beta

  • TFIIE beta subunit

GTF2E2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
GTF2E2 P29084 KAT5 Homo sapiens Q92993
Validated Y2H
32296183
Intra
GTF2E2 P29084 GTF2E1 Homo sapiens P29083
Anti Tag CoIP
33961781
Intra
GTF2E2 P29084 GTF2E1 Homo sapiens P29083
EM
16547462
Intra
GTF2E2 P29084 GTF2E1 Homo sapiens P29083
Y2H Prey Pooling
32296183
Intra
GTF2E2 P29084 GTF2E1 Homo sapiens P29083
Crosslink
16547462
Intra
GTF2E2 P29084 GTF2E1 Homo sapiens P29083
Y2H Array
32296183
Intra
GTF2E2 P29084 GTF2E1 Homo sapiens P29083
Anti Tag CoIP
28514442
Intra
GTF2E2 P29084 EXOC8 Homo sapiens Q8IYI6
Y2H Array
32296183
Intra
GTF2E2 P29084 EXOC8 Homo sapiens Q8IYI6
Validated Y2H
32296183
Intra
GTF2E2 P29084 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
GTF2E2 P29084 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
GTF2E2 P29084 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

GTF2E2 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P810885 GTF2E2 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Trichothiodystrophy 6, Nonphotosensitive

  • TTD6

  • Nonphotosensitive Trichothiodystrophy 6

  • Trichothiodystrophy 6, Non-Photosensitive
Trichothiodystrophy

  • Ttd

  • Amish Brittle Hair Syndrome

  • Bids Syndrome

  • Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome

  • Ibids

  • Pibids

  • Trichothiodystrophy Syndromes
Ichthyosis

  • Ichthyoses

  • Non-Syndromic Ichthyosis

  • Congenital Ichthyosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS05895 GTF2E2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GTF2E2 VGNC VGNC:41545
Mus musculus GTF2E2 MGD MGI:1915403
Rattus norvegicus GTF2E2 RGD RGD:1310134
Bos taurus GTF2E2 VGNC VGNC:29694
Felis catus GTF2E2 VGNC VGNC:67496
Macaca mulatta GTF2E2 VGNC VGNC:73308
Others GTF2E2 NCBI