1. Immunology/Inflammation
  2. NOD-like Receptor (NLR)
  3. MCC7840 sodium

MCC7840 sodium 

Cat. No.: HY-137245A
Handling Instructions

MCC7840 sodium, a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of <100 nM. MCC7840 sodium can be used for the research of inflammatory diseases.

For research use only. We do not sell to patients.

MCC7840 sodium Chemical Structure

MCC7840 sodium Chemical Structure

CAS No. : 2380032-29-9

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Description

MCC7840 sodium, a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of <100 nM. MCC7840 sodium can be used for the research of inflammatory diseases[1][2].

IC50 & Target[1]

NLRP3 inflammasome

<100 nM (IC50)

In Vitro

MCC7840, a MCC950 analogue, shows useful activity in the inhibition of activation of the NLRP3 inflammasome, with an IC50 of <100 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MCC7840 (4 mg/kg; i.v.) exhibits the half-life (3.39 h), AUC0-last (107097 ng•h/mL) and CL (0.621 mL/min/kg) in mice[2].
MCC7840 (20 mg/kg; p.o.) exhibits the oral bioavailability (67.2%), Cmax (60467 ng/mL) and half-life (5.02 h) in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice (7-9 weeks)[2]
Dosage: 4 mg/kg for i.v. and 20 mg/kg for p.o. (Pharmacokinetic Analysis)
Administration: A single intravenousbolus or oral gavage
Result: I.v.: t1/2=3.39 h; AUC0-last=107097 ng•h/mL; CL=0.621 mL/min/kg.
P.o.: F=67.2%; Cmax=60467 ng/mL; t1/2=5.02 h.
Molecular Weight

410.47

Formula

C₁₉H₂₃N₄NaO₃S

CAS No.

2380032-29-9

SMILES

O=S(C1=NN(C(C)C)C=C1)([N-]C(NC2=C3CCCC3=CC4=C2CCC4)=O)=O.[Na+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

MCC7840MCC 7840MCC-7840NOD-like Receptor (NLR)sulfonylureaNLRP3inflammasomeinflammatoryInhibitorinhibitorinhibit

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MCC7840 sodium
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HY-137245A
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