IMP3 - IMP U3 small nucleolar ribonucleoprotein 3 Gene

Also Known as BRMS2; MRPS4; C15orf12

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55272

About IMP3

Cytogenetic location: 15q24.2 Genomic coordinates (GRCh38): 15:75,639,093-75,640,224 (from NCBI)

This gene has 3 transcripts (splice variants) and 184 orthologues.

Summary

This gene encodes the human homolog of the yeast Imp3 protein. The protein localizes to the nucleoli and interacts with the U3 snoRNP complex. The protein contains an S4 domain. [provided by RefSeq, Jul 2008]

IMP3 Products (1)

mRNA Protein Name
NM_018285.4 NP_060755.1 U3 small nucleolar ribonucleoprotein protein IMP3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12655004 GOA
Biological Process GO Annotation Evidence References Source
involved in ribosomal small subunit biogenesis IDA
IDA: Inferred from direct assay
34516797 GOA
Cellular Component GO Annotation Evidence References Source
part of Mpp10 complex IDA
IDA: Inferred from direct assay
12655004 GOA
part of Mpp10 complex IPI
IPI: Inferred from physical interaction
12655004 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
12655004 GOA
part of preribosome IDA
IDA: Inferred from direct assay
12655004 GOA
part of small-subunit processome IDA
IDA: Inferred from direct assay
34516797 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IMP3 Protein Structure

S4

S4: S4 domain (109 - 154)

  • 0
  • 100
  • 184 a.a.
Protein Preferred Names Protein Names

U3 small nucleolar ribonucleoprotein protein IMP3

  • IMP3, U3 small nucleolar ribonucleoprotein, homolog

IMP3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IMP3 Q9NV31 TFIP11 Homo sapiens Q9UBB9
Y2H Array
25416956
Intra
IMP3 Q9NV31 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
25416956
Intra
IMP3 Q9NV31 TFIP11 Homo sapiens Q9UBB9
Y2H Array
31515488
Intra
IMP3 Q9NV31 NANOS3 Homo sapiens P60323-2
Y2H Array
32296183
Intra
IMP3 Q9NV31 NANOS3 Homo sapiens P60323-2
Y2H Prey Pooling
32296183
Intra
IMP3 Q9NV31 MCC Homo sapiens P23508
Anti Tag CoIP
33961781
Intra
IMP3 Q9NV31 MCC Homo sapiens P23508
Y2H Array
32296183
Intra
IMP3 Q9NV31 MCC Homo sapiens P23508
Y2H Prey Pooling
32296183
Intra
IMP3 Q9NV31 ZYX Homo sapiens Q15942
Y2H Array
31515488
Intra
IMP3 Q9NV31 ZYX Homo sapiens Q15942
Y2H Prey Pooling
32296183
Intra
IMP3 Q9NV31 ZYX Homo sapiens Q15942
Y2H Prey Pooling
25416956
Intra
IMP3 Q9NV31 ZYX Homo sapiens Q15942
Y2H Array
32296183
Intra
IMP3 Q9NV31 ZYX Homo sapiens Q15942
Y2H Array
29892012
Intra
IMP3 Q9NV31 MPHOSPH10 Homo sapiens O00566
Anti Tag CoIP
35271311
Intra
IMP3 Q9NV31 MPHOSPH10 Homo sapiens O00566
Pull Down
12655004
Intra
IMP3 Q9NV31 MPHOSPH10 Homo sapiens O00566
Anti Tag CoIP
33961781
Intra
IMP3 Q9NV31 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra
IMP3 Q9NV31 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra
IMP3 Q9NV31 PPP1R12C Homo sapiens Q9BZL4
Y2H Prey Pooling
32296183
Intra
IMP3 Q9NV31 PPP1R12C Homo sapiens Q9BZL4
Y2H Array
32296183
Intra
IMP3 Q9NV31 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
32296183
Intra
IMP3 Q9NV31 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
25416956
Intra
IMP3 Q9NV31 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
32296183
Intra
IMP3 Q9NV31 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
Intra
IMP3 Q9NV31 SORBS3 Homo sapiens O60504
Y2H Array
32296183
Intra
IMP3 Q9NV31 SERTAD3 Homo sapiens Q9UJW9
Y2H Prey Pooling
32296183
Intra
IMP3 Q9NV31 SERTAD3 Homo sapiens Q9UJW9
Y2H Array
32296183
Intra
IMP3 Q9NV31 SERTAD3 Homo sapiens Q9UJW9
Validated Y2H
32296183
Intra
IMP3 Q9NV31 CCNDBP1 Homo sapiens O95273
Y2H Array
31515488
Intra
IMP3 Q9NV31 CCNDBP1 Homo sapiens O95273
Y2H Prey Pooling
25416956
Intra
IMP3 Q9NV31 CCNDBP1 Homo sapiens O95273
Y2H Array
19060904
Intra
IMP3 Q9NV31 CCNDBP1 Homo sapiens O95273
Y2H Pooling
19060904
Intra
IMP3 Q9NV31 EVI5 Homo sapiens O60447
Y2H Prey Pooling
32296183
Intra
IMP3 Q9NV31 EVI5 Homo sapiens O60447
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Dermatosis Papulosa Nigra
Melanoacanthoma
Animal Phobia

  • Zoophobia

  • Fear Of Animals
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06621 IGF2BP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17518 Igf2bp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06793 IMP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13704 SPPL2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17960 Imp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24431 Imp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris IMP3 VGNC VGNC:42006
Macaca mulatta IMP3 VGNC VGNC:73594
Mus musculus IMP3 MGD MGI:1916119
Bos taurus IMP3 VGNC VGNC:30182
Rattus norvegicus IMP3 RGD RGD:1306825
Others IMP3 NCBI