EVI5 - ecotropic viral integration site 5 Gene

Also Known as NB4S; EVI-5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7813

About EVI5

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:92,508,696-92,792,410 (from NCBI)

This gene has 9 transcripts (splice variants), 211 orthologues and 45 paralogues. Ubiquitous expression in testis (RPKM 3.8), placenta (RPKM 3.5) and 25 other tissues.

Summary

Enables GTPase activator activity and small GTPase binding activity. Involved in positive regulation of GTPase activity and retrograde transport, endosome to Golgi. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

EVI5 Products (8)

mRNA Protein Name
NM_001308248.2 NP_001295177.1 ecotropic viral integration site 5 protein homolog isoform 1
NM_001350197.2 NP_001337126.1 ecotropic viral integration site 5 protein homolog isoform 3
NM_001350198.2 NP_001337127.1 ecotropic viral integration site 5 protein homolog isoform 4
NM_001377210.1 NP_001364139.1 ecotropic viral integration site 5 protein homolog isoform 5
NM_001377211.1 NP_001364140.1 ecotropic viral integration site 5 protein homolog isoform 6
NM_001377212.1 NP_001364141.1 ecotropic viral integration site 5 protein homolog isoform 7
NM_001377213.1 NP_001364142.1 ecotropic viral integration site 5 protein homolog isoform 8
NM_005665.6 NP_005656.4 ecotropic viral integration site 5 protein homolog isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
17562788 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16439210 GOA
enables small GTPase binding IPI
IPI: Inferred from physical interaction
17562788 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
17562788 GOA
NOT involved in regulation of cilium assembly IMP
IMP: Inferred from mutant phenotype
17646400 GOA
involved in retrograde transport, endosome to Golgi IMP
IMP: Inferred from mutant phenotype
17562788 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
17562788 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EVI5 Protein Structure

RabGAP-TBC

RabGAP-TBC: Rab-GTPase-TBC domain (167 - 368)

  • 0
  • 200
  • 400
  • 600
  • 810 a.a.
Protein Preferred Names Protein Names

ecotropic viral integration site 5 protein homolog

  • dJ846D11.1 (ecotropic viral integration site 5)

EVI5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EVI5 O60447 MB21D2 Homo sapiens Q8IYB1
Anti Tag CoIP
33961781
Intra
EVI5 O60447 MB21D2 Homo sapiens Q8IYB1
Validated Y2H
32296183
Intra
EVI5 O60447 TCEANC Homo sapiens Q8N8B7-2
Validated Y2H
32296183
Intra
EVI5 O60447 REP15 Homo sapiens Q6BDI9
Validated Y2H
32296183
Intra
EVI5 O60447 PRPF31 Homo sapiens Q8WWY3
Validated Y2H
32296183
Intra
EVI5 O60447 ARL4A Homo sapiens P40617
Validated Y2H
32296183
Intra
EVI5 O60447 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
32296183
Intra
EVI5 O60447 MORF4L2 Homo sapiens Q15014
Validated Y2H
32296183
Intra
EVI5 O60447 FAM161A Homo sapiens Q3B820
Validated Y2H
32296183
Intra
EVI5 O60447 LENG1 Homo sapiens Q96BZ8
Validated Y2H
32296183
Intra
EVI5 O60447 ZNF446 Homo sapiens Q9NWS9-2
Validated Y2H
32296183
Intra
EVI5 O60447 CCDC185 Homo sapiens Q8N715
Validated Y2H
32296183
Intra
EVI5 O60447 CEP19 Homo sapiens Q96LK0
Validated Y2H
32296183
Intra
EVI5 O60447 ELOA Homo sapiens Q14241
Validated Y2H
32296183
Intra
EVI5 O60447 RAB11A Homo sapiens P62491
SPR
17229837
Intra
EVI5 O60447 RAB11A Homo sapiens P62491
Y2H
17229837
Intra
EVI5 O60447 RAB11A Homo sapiens P62491
Pull Down
17229837
Intra
EVI5 O60447 RAB11A Homo sapiens P62491
Anti Bait CoIP
17229837
Intra
EVI5 O60447 IMP3 Homo sapiens Q9NV31
Validated Y2H
32296183
Intra
EVI5 O60447 CSNK1D Homo sapiens P48730
Validated Y2H
32296183
Intra
EVI5 O60447 TNFAIP8L1 Homo sapiens Q8WVP5
Validated Y2H
32296183
Intra
EVI5 O60447 FBXO5 Homo sapiens Q9UKT4
Anti Bait CoIP
16439210
Intra
EVI5 O60447 FBXO5 Homo sapiens Q9UKT4
Anti Tag CoIP
16439210
Intra
EVI5 O60447 LMO1 Homo sapiens P25800
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Neuroblastoma

  • Nb

  • Neuroblastoma, Susceptibility To

  • Neuroblastomas

  • Central Neuroblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04576 EVI5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta EVI5 VGNC VGNC:99919
Bos taurus EVI5 VGNC VGNC:55170
Rattus norvegicus EVI5 RGD RGD:2322879
Mus musculus EVI5 MGD MGI:104736
Felis catus EVI5 VGNC VGNC:80209
Others EVI5 NCBI