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FBXO5 - F-box protein 5 Gene

Also Known as EMI1; FBX5; Fbxo31

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26271

About FBXO5

Cytogenetic location: 6q25.2 Genomic coordinates (GRCh38): 6:152,970,535-152,983,579 (from NCBI)

This gene has 3 transcripts (splice variants), 195 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 14.0), lymph node (RPKM 6.9) and 22 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008]

FBXO5 Products (2)

mRNA	Protein	Name
NM_001142522.3	NP_001135994.1	F-box only protein 5 isoform b
NM_012177.5	NP_036309.1	F-box only protein 5 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables anaphase-promoting complex binding	IDA IDA: Inferred from direct assay	16921029	GOA
enables molecular function inhibitor activity	IDA IDA: Inferred from direct assay	23708605	GOA
enables molecular function inhibitor activity	IMP IMP: Inferred from mutant phenotype	23708605	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11988738	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	15148369	GOA
enables ubiquitin ligase inhibitor activity	IDA IDA: Inferred from direct assay	15148369	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	17875940	GOA
involved in negative regulation of DNA endoreduplication	IMP IMP: Inferred from mutant phenotype	17875940	GOA
involved in negative regulation of cellular senescence	IMP IMP: Inferred from mutant phenotype	17875940	GOA
involved in negative regulation of mitotic metaphase/anaphase transition	IDA IDA: Inferred from direct assay	11988738	GOA
involved in negative regulation of ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	11988738	GOA
involved in negative regulation of ubiquitin protein ligase activity	IMP IMP: Inferred from mutant phenotype	23708605	GOA
involved in negative regulation of ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	23708001	GOA
involved in positive regulation of G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	17485488	GOA
involved in positive regulation of biomineral tissue development	IMP IMP: Inferred from mutant phenotype	29850565	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17234884	GOA
involved in positive regulation of mesenchymal stem cell migration	IMP IMP: Inferred from mutant phenotype	29850565	GOA
involved in positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	29850565	GOA
involved in regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	17234884	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11988738	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11988738	GOA
located in spindle	IDA IDA: Inferred from direct assay	15469984	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXO5 Protein Structure

F-box

0
100
200
300
400
447 a.a.

Protein Preferred Names	Protein Names
F-box only protein 5	F-box protein Fbx5

FBXO5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FBXO5	Q9UKT4	EVI5	Homo sapiens	O60447	Anti Tag CoIP	16439210
Intra	FBXO5	Q9UKT4	EVI5	Homo sapiens	O60447	Pull Down	16439210
Intra	FBXO5	Q9UKT4	CDC27	Homo sapiens	P30260	Anti Tag CoIP	33961781
Intra	FBXO5	Q9UKT4	CDC27	Homo sapiens	P30260	Anti Bait CoIP	17719540

Cross: Cross-species interaction Intra: Intraspecies interaction

FBXO5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82488	Emi1 Antibody (YA2233)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Aleutian Mink Disease	Aleutian Disease
Arthrogryposis Multiplex Congenita 2, Neurogenic Type	Arthrogryposis Multiplex Congenita, Neurogenic Type Amcn Arthrogryposis Multiplex Congenita Neurogenic Type AMC2 Amc, Neurogenic Type Neurogenic-Type Arthrogryposis Multiplex Congenita-2 Amc Neurogenic Type Neurogenic Type Of Amc Neurogenic Arthrogryposis Multiplex Congenita Arthrogryposis Multiplex Congenita, Neurogenic
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04811	FBXO5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21570	Fbxo5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28088	Fbxo5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FBXO5	VGNC	VGNC:62196
Canis familiaris	FBXO5	VGNC	VGNC:40787
Mus musculus	FBXO5	MGD	MGI:1914391
Macaca mulatta	FBXO5	VGNC	VGNC:72489
Rattus norvegicus	FBXO5	RGD	RGD:1309405
Bos taurus	FBXO5	VGNC	VGNC:28917
Others	FBXO5	NCBI