CDC27 - cell division cycle 27 Gene

Homo sapiens

Also known as APC3; HNUC; NUC2; H-NUC; ANAPC3; CDC27Hs; D0S1430E; D17S978E

Gene ID: 996 | Gene type: protein coding

About CDC27

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:47,117,703-47,189,295 (from NCBI)

This gene has 19 transcripts (splice variants), 205 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 20.3), testis (RPKM 11.6) and 25 other tissues.

Summary

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014]

CDC27 Products(9)

mRNA	Protein	Name
NM_001114091.4	NP_001107563.1	cell division cycle protein 27 homolog isoform 1
NM_001256.6	NP_001247.3	cell division cycle protein 27 homolog isoform 2
NM_001293089.3	NP_001280018.1	cell division cycle protein 27 homolog isoform 3
NM_001293091.3	NP_001280020.1	cell division cycle protein 27 homolog isoform 4
NM_001353035.2	NP_001339964.1	cell division cycle protein 27 homolog isoform 5
NM_001353047.2	NP_001339976.1	cell division cycle protein 27 homolog isoform 6
NM_001353049.2	NP_001339978.1	cell division cycle protein 27 homolog isoform 7
NM_001353050.2	NP_001339979.1	cell division cycle protein 27 homolog isoform 8
NM_001353051.2	NP_001339980.1	cell division cycle protein 27 homolog isoform 9

CDC27 Protein Structure

ANAPC3

TPR_1

TPR_11

TPR_1

TPR_11

0
200
400
600
824 a.a.

Protein Preferred Names

Protein Names

cell division cycle protein 27 homolog

D0S1430E, D17S978E

Related Diseases

Diseases

Alias

Glandular Tularemia

Pyomyositis

Tropical Pyomyositis	Myositis Tropicans
Myositis Purulenta Tropica	Pm
Suppurative Myositis	Purulent Myositis

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02295	CDC27 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CDC27	VGNC	VGNC:60653
Mus musculus	CDC27	MGD	MGI:102685
Rattus norvegicus	CDC27	RGD	RGD:1304921
Bos taurus	CDC27	VGNC	VGNC:50040
Canis familiaris	CDC27	VGNC	VGNC:53202
Macaca mulatta	CDC27	VGNC	VGNC:70797

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