1. Gene
  2. FZR1 - fizzy and cell division cycle 20 related 1 Gene

FZR1 - fizzy and cell division cycle 20 related 1 Gene

Homo sapiens

Also known as FZR; CDH1; FZR2; HCDH; HCDH1; CDC20C; DEE109

Gene ID: 51343 | Gene type: protein coding

About FZR1

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,506,311-3,538,334 (from NCBI)

This gene has 9 transcripts (splice variants), 260 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 11.7), bone marrow (RPKM 10.3) and 25 other tissues.

Summary

Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Involved in anaphase-promoting complex-dependent catabolic process; mitotic G2 DNA damage checkpoint signaling; and positive regulation of protein metabolic process. Located in nuclear membrane and nucleoplasm. Colocalizes with anaphase-promoting complex. [provided by Alliance of Genome Resources, Apr 2022]

FZR1 Products(3)

mRNA Protein Name
NM_001136197.1 NP_001129669.1 fizzy-related protein homolog isoform 3
NM_001136198.1 NP_001129670.1 fizzy-related protein homolog isoform 1
NM_016263.4 NP_057347.2 fizzy-related protein homolog isoform 2

FZR1 Protein Structure

WD40

WD40: WD domain, G-beta repeat (230 - 257)

WD40

WD40: WD domain, G-beta repeat (262 - 293)

WD40

WD40: WD domain, G-beta repeat (307 - 341)

WD40

WD40: WD domain, G-beta repeat (347 - 386)

WD40

WD40: WD domain, G-beta repeat (435 - 471)

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  • 496 a.a.
Protein Preferred Names Protein Names

fizzy-related protein homolog

CDC20 homolog 1

Related Diseases

Diseases Alias
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus FZR1 VGNC VGNC:62408
Canis familiaris FZR1 VGNC VGNC:41036
Macaca mulatta FZR1 VGNC VGNC:72774
Bos taurus FZR1 VGNC VGNC:29173
Rattus norvegicus FZR1 RGD RGD:1308713
Mus musculus FZR1 MGD MGI:1926790