CLSPN - claspin Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 63967

About CLSPN

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:35,720,213-35,769,978 (from NCBI)

This gene has 6 transcripts (splice variants) and 211 orthologues. Broad expression in bone marrow (RPKM 2.6), testis (RPKM 2.4) and 16 other tissues.

Summary

The product of this gene is an essential upstream regulator of checkpoint kinase 1 and triggers a checkpoint arrest of the cell cycle in response to replicative stress or DNA damage. The protein is also required for efficient DNA replication during a normal S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

CLSPN Products (3)

mRNA Protein Name
NM_001190481.2 NP_001177410.1 claspin isoform 2
NM_001330490.2 NP_001317419.1 claspin isoform 3
NM_022111.4 NP_071394.2 claspin isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA secondary structure binding IDA
IDA: Inferred from direct assay
5226314 GOA
enables anaphase-promoting complex binding IPI
IPI: Inferred from physical interaction
18662541 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16885022 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
16963448 GOA
acts upstream of DNA replication checkpoint signaling IDA
IDA: Inferred from direct assay
16123041 GOA
acts upstream of or within DNA replication checkpoint signaling IDA
IDA: Inferred from direct assay
12766152 GOA
involved in activation of protein kinase activity IDA
IDA: Inferred from direct assay
16885022 GOA
involved in mitotic DNA replication checkpoint signaling IMP
IMP: Inferred from mutant phenotype
16885022 GOA
involved in mitotic G2 DNA damage checkpoint signaling IDA
IDA: Inferred from direct assay
18662541 GOA
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
16885022 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12766152 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

claspin

  • claspin homolog

CLSPN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CLSPN Q9HAW4 CDC45 Homo sapiens O75419
Pull Down
23910567
Intra
CLSPN Q9HAW4 CHEK1 Homo sapiens O14757
Protein Kinase Assay
16963448
Intra
CLSPN Q9HAW4 CHEK1 Homo sapiens O14757
Pull Down
16963448
Intra
CLSPN Q9HAW4 CHEK1 Homo sapiens O14757
Anti Tag CoIP
16963448
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ataxia-Telangiectasia

  • Ataxia Telangiectasia

  • Louis-Bar Syndrome

  • AT

  • At1

  • Ataxia-Telangiectasia Syndrome

  • Ataxia - Telangiectasia Variant

  • Boder-Sedgwick Syndrome

  • Louis Bar Syndrome

  • Cerebello-Oculocutaneous Telangiectasia

  • Immunodeficiency With Ataxia Telangiectasia

  • A-T

  • Ataxia Telangiectasia Syndrome

  • Atm

  • Telangiectasia, Cerebello-Oculocutaneous

  • Ataxia-Telangiectasia Variant
Xeroderma Pigmentosum, Variant Type

  • Xeroderma Pigmentosum

  • XPV

  • Xeroderma Pigmentosum Variant Type

  • Xeroderma Pigmentosum With Normal Dna Repair Rates

  • Photosensitivity With Defective Dna Synthesis

  • Xp

  • De Sanctis-Cacchione Syndrome

  • Desanctis-Cacchione Syndrome

  • Xeroderma Pigmentosa

  • Xerodermic Idiocy

  • Xeroderma Pigmentosum Variant

  • Xp - [Xeroderma Pigmentosum]

  • Atrophoderma Pigmentosum
Seckel Syndrome

  • Microcephalic Primordial Dwarfism

  • Bird-Headed Dwarfism

  • Harper'S Syndrome

  • Virchow-Seckel Dwarfism

  • Nanocephalic Dwarfism

  • Sckl

  • Seckel-Type Dwarfism
Fanconi Anemia, Complementation Group A

  • Fanconi Anemia

  • Fanconi Pancytopenia

  • Fanconi Anemia Complementation Group A

  • FANCA

  • Fa

  • Fanconi Panmyelopathy

  • Fanconi'S Anemia

  • Fanconi Anaemia

  • Fanconi'S Anaemia

  • Fanconi Hypoplastic Anemia

  • Estren-Dameshek Variant Of Fanconi Anemia

  • Estren-Dameshek Variant Of Fanconi Pancytopenia

  • Fanconi Anemia Estren-Dameshek Variant

  • Fanconis Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02839 CLSPN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CLSPN RGD RGD:1309083
Macaca mulatta CLSPN VGNC VGNC:99869
Bos taurus CLSPN VGNC VGNC:27465
Canis familiaris CLSPN VGNC VGNC:39362
Felis catus CLSPN VGNC VGNC:60978
Mus musculus CLSPN MGD MGI:2445153
Others CLSPN NCBI