RAD17 - RAD17 checkpoint clamp loader component Gene

Also Known as CCYC; R24L; RAD24; HRAD17; RAD17SP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5884

About RAD17

Cytogenetic location: 5q13.2 Genomic coordinates (GRCh38): 5:69,369,293-69,414,801 (from NCBI)

This gene has 20 transcripts (splice variants), 1 gene allele, 199 orthologues and is associated with 59 phenotypes. Broad expression in testis (RPKM 28.4), lymph node (RPKM 9.8) and 25 other tissues.

Summary

The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013]

RAD17 Products (9)

mRNA Protein Name
NM_001278622.1 NP_001265551.1 cell cycle checkpoint protein RAD17 isoform 1
NM_002873.1 NP_002864.1 cell cycle checkpoint protein RAD17 isoform 1
NM_133338.3 NP_579916.1 cell cycle checkpoint protein RAD17 isoform 1
NM_133339.2 NP_579917.1 cell cycle checkpoint protein RAD17 isoform 2
NM_133340.2 NP_579918.1 cell cycle checkpoint protein RAD17 isoform 3
NM_133341.2 NP_579919.1 cell cycle checkpoint protein RAD17 isoform 4
NM_133342.3 NP_579920.1 cell cycle checkpoint protein RAD17 isoform 1
NM_133343.2 NP_579921.1 cell cycle checkpoint protein RAD17 isoform 1
NM_133344.3 NP_579922.1 cell cycle checkpoint protein RAD17 isoform 1

RAD17 Protein Structure

Rad17

Rad17: Rad17 cell cycle checkpoint protein (84 - 593)

  • 0
  • 200
  • 400
  • 600
  • 681 a.a.
Protein Preferred Names Protein Names

cell cycle checkpoint protein RAD17

  • RAD1 homolog

RAD17 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RAD17 O75943 MRE11 Homo sapiens P49959
Anti Bait CoIP
24534091
Intra
RAD17 O75943 NBN Homo sapiens O60934
Pull Down
24534091
Intra
RAD17 O75943 NBN Homo sapiens O60934
Anti Bait CoIP
24534091
Intra
RAD17 O75943 RAD50 Homo sapiens Q92878
Anti Bait CoIP
24534091
Intra
RAD17 O75943 FZR1 Homo sapiens Q9UM11
Anti Bait CoIP
20424596
Cross: Cross-species interaction Intra: Intraspecies interaction

RAD17 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82895 Phospho-Rad17 (Ser656) Antibody (YA2640) WB, IHC-F, IHC-P, ICC/IF Human
HY-P82895A Phospho-Rad17 (Ser656) Antibody (YA2640)(PBS only) WB, IHC-F, IHC-P, ICC/IF Human

Related Diseases

Diseases Alias
Seminoma

  • Seminoma, Pure
Ataxia-Telangiectasia

  • Ataxia Telangiectasia

  • Louis-Bar Syndrome

  • AT

  • At1

  • Ataxia-Telangiectasia Syndrome

  • Ataxia - Telangiectasia Variant

  • Boder-Sedgwick Syndrome

  • Louis Bar Syndrome

  • Cerebello-Oculocutaneous Telangiectasia

  • Immunodeficiency With Ataxia Telangiectasia

  • A-T

  • Ataxia Telangiectasia Syndrome

  • Atm

  • Telangiectasia, Cerebello-Oculocutaneous

  • Ataxia-Telangiectasia Variant
Nijmegen Breakage Syndrome

  • Berlin Breakage Syndrome

  • NBS

  • Microcephaly, Normal Intelligence And Immunodeficiency

  • Ataxia-Telangiectasia Variant

  • Ataxia-Telangiectasia Variant V1

  • Seemanova Syndrome Ii

  • Immunodeficiency-Microcephaly-Chromosomal Instability Syndrome

  • Seemanova Syndrome Type 2

  • At-V1

  • Microcephaly With Normal Intelligence, Immunodeficiency, And Lymphoreticular Malignancies

  • Nonsyndromal Microcephaly, Autosomal Recessive, With Normal Intelligence

  • Immunodeficiency, Microcephaly, And Chromosomal Instability

  • Microcephaly-Immunodeficiency-Lymphoreticuloma Syndrome

  • Microcephaly Immunodeficiency Lymphoreticuloma

  • Microcephaly With Normal Intelligence Immunodeficiency And Lymphoreticular Malignancies

  • Nonsyndromal Microcephaly Autosomal Recessive With Normal Intelligence

  • Seemanova Syndrome 2

  • Ataxia-Telangiectasia Variant 1

  • Seemanova Syndrome

  • At V1

  • Ataxia-Telangiectasia, Variant 1

  • Microcephaly-Immunodeficiency-Lymphoid Malignancy Syndrome

  • V-At

  • Ataxia Telangiectasia Variant V1
Fanconi Anemia, Complementation Group A

  • Fanconi Anemia

  • Fanconi Pancytopenia

  • Fanconi Anemia Complementation Group A

  • FANCA

  • Fa

  • Fanconi Panmyelopathy

  • Fanconi'S Anemia

  • Fanconi Anaemia

  • Fanconi'S Anaemia

  • Fanconi Hypoplastic Anemia

  • Estren-Dameshek Variant Of Fanconi Anemia

  • Estren-Dameshek Variant Of Fanconi Pancytopenia

  • Fanconi Anemia Estren-Dameshek Variant

  • Fanconis Anemia
Seckel Syndrome

  • Microcephalic Primordial Dwarfism

  • Bird-Headed Dwarfism

  • Harper'S Syndrome

  • Virchow-Seckel Dwarfism

  • Nanocephalic Dwarfism

  • Sckl

  • Seckel-Type Dwarfism
Melanoma, Cutaneous Malignant 1

  • Familial Melanoma

  • Melanoma, Cutaneous Malignant, Susceptibility To, 1

  • Melanoma, Malignant

  • CMM1

  • Melanoma, Cutaneous Malignant

  • Cmm

  • Familial Atypical Mole-Malignant Melanoma Syndrome

  • Fammm

  • Melanoma, Familial

  • Mlm

  • Dysplastic Nevus Syndrome, Hereditary

  • Dns

  • B-K Mole Syndrome

  • Melanoma, Cutaneous Malignant, 1

  • Malignant Melanoma, Cutaneous

  • Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1

  • Dysplastic Nevus Syndrome

  • Cutaneous Melanoma

  • Familial Atypical Mole Melanoma Syndrome

  • Hereditary Melanoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11597 RAD17 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RAD17 RGD RGD:1309515
Canis familiaris RAD17 VGNC VGNC:45311
Macaca mulatta RAD17 VGNC VGNC:84484
Felis catus RAD17 VGNC VGNC:69211
Mus musculus RAD17 MGD MGI:1333807
Bos taurus RAD17 VGNC VGNC:33678
Others RAD17 NCBI