TNFAIP8L1 - TNF alpha induced protein 8 like 1 Gene

Also Known as TIPE1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 126282

About TNFAIP8L1

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,639,516-4,655,568 (from NCBI)

This gene has 3 transcripts (splice variants), 185 orthologues and 3 paralogues. Ubiquitous expression in liver (RPKM 6.4), spleen (RPKM 5.8) and 24 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in negative regulation of TOR signaling. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TNFAIP8L1 Products (2)

mRNA Protein Name
NM_001167942.1 NP_001161414.1 tumor necrosis factor alpha-induced protein 8-like protein 1
NM_152362.3 NP_689575.2 tumor necrosis factor alpha-induced protein 8-like protein 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFAIP8L1 Protein Structure

DUF758

DUF758: Domain of unknown function (DUF758) (1 - 186)

  • 0
  • 100
  • 186 a.a.
Protein Preferred Names Protein Names

tumor necrosis factor alpha-induced protein 8-like protein 1

  • TNF alpha-induced protein 8-like protein 1

TNFAIP8L1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TNFAIP8L1 Q8WVP5 ANKRD36B Homo sapiens Q8N2N9-4
Y2H Array
32296183
Intra
TNFAIP8L1 Q8WVP5 ANKRD36B Homo sapiens Q8N2N9-4
Y2H Prey Pooling
32296183
Intra
TNFAIP8L1 Q8WVP5 CAVIN1 Homo sapiens Q6NZI2
Y2H Array
32296183
Intra
TNFAIP8L1 Q8WVP5 CAVIN1 Homo sapiens Q6NZI2
Y2H Prey Pooling
32296183
Intra
TNFAIP8L1 Q8WVP5 PSME3 Homo sapiens P61289
Y2H Array
32296183
Intra
TNFAIP8L1 Q8WVP5 PSME3 Homo sapiens P61289
Y2H Prey Pooling
25416956
Intra
TNFAIP8L1 Q8WVP5 PSME3 Homo sapiens P61289
Y2H Prey Pooling
32296183
Intra
TNFAIP8L1 Q8WVP5 MED4 Homo sapiens Q9NPJ6
Y2H Prey Pooling
32296183
Intra
TNFAIP8L1 Q8WVP5 MED4 Homo sapiens Q9NPJ6
Validated Y2H
32296183
Intra
TNFAIP8L1 Q8WVP5 MED4 Homo sapiens Q9NPJ6
Y2H Array
32296183
Intra
TNFAIP8L1 Q8WVP5 DVL3 Homo sapiens Q92997
Y2H Array
32296183
Intra
TNFAIP8L1 Q8WVP5 DVL3 Homo sapiens Q92997
Y2H Prey Pooling
32296183
Intra
TNFAIP8L1 Q8WVP5 DVL3 Homo sapiens Q92997
Validated Y2H
32296183
Intra
TNFAIP8L1 Q8WVP5 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
Intra
TNFAIP8L1 Q8WVP5 STAC3 Homo sapiens Q96MF2
Y2H Array
32296183
Intra
TNFAIP8L1 Q8WVP5 STAC3 Homo sapiens Q96MF2
Validated Y2H
32296183
Intra
TNFAIP8L1 Q8WVP5 STAC3 Homo sapiens Q96MF2
Y2H Prey Pooling
32296183
Intra
TNFAIP8L1 Q8WVP5 EVI5 Homo sapiens O60447
Y2H Prey Pooling
32296183
Intra
TNFAIP8L1 Q8WVP5 EVI5 Homo sapiens O60447
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Colon Mucinous Adenocarcinoma

  • Colonic Mucinous Adenocarcinoma

  • Mucinous Adenocarcinoma Of The Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14792 TNFAIP8L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TNFAIP8L1 RGD RGD:1588574
Bos taurus TNFAIP8L1 VGNC VGNC:36158
Felis catus TNFAIP8L1 VGNC VGNC:66400
Macaca mulatta TNFAIP8L1 VGNC VGNC:79694
Mus musculus TNFAIP8L1 MGD MGI:1913693
Others TNFAIP8L1 NCBI