REP15 - RAB15 effector protein Gene

Also Known as RAB15EP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 387849

About REP15

Cytogenetic location: 12p11.22 Genomic coordinates (GRCh38): 12:27,696,447-27,697,596 (from NCBI)

This gene has 1 transcript (splice variant) and 93 orthologues.

Summary

The protein encoded by this intronless gene interacts with GTP-bound Rab15 and is involved in recycling of Transferrin Receptor from the endocytic recycling compartment to the cell surface. [provided by RefSeq, Sep 2016]

REP15 Products (1)

mRNA Protein Name
NM_001029874.3 NP_001025045.3 rab15 effector protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16195351 GOA
Biological Process GO Annotation Evidence References Source
involved in receptor recycling IMP
IMP: Inferred from mutant phenotype
16195351 GOA
involved in transferrin transport IDA
IDA: Inferred from direct assay
16195351 GOA
Cellular Component GO Annotation Evidence References Source
located in endosome membrane IDA
IDA: Inferred from direct assay
16195351 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16195351 GOA
located in recycling endosome IDA
IDA: Inferred from direct assay
16195351 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

REP15 Protein Structure

Rab15_effector

Rab15_effector: Rab15 effector (1 - 236)

  • 0
  • 100
  • 200
  • 236 a.a.
Protein Preferred Names Protein Names

rab15 effector protein

REP15 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
REP15 Q6BDI9 ARID3A Homo sapiens Q99856
Validated Y2H
32296183
Intra
REP15 Q6BDI9 EVI5 Homo sapiens O60447
Y2H Array
32296183
Intra
REP15 Q6BDI9 EVI5 Homo sapiens O60447
Anti Tag CoIP
33961781
Intra
REP15 Q6BDI9 EVI5 Homo sapiens O60447
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Eiken Syndrome

  • Eiken Skeletal Dysplasia

  • Bone Modeling Defect Of Hands And Feet

  • EKNS
Pancreatic Acinar Cell Adenocarcinoma

  • Pancreatic Acinar Cell Carcinoma

  • Acinar Cell Adenocarcinoma Of The Pancreas
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11843 REP15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus REP15 VGNC VGNC:33867
Mus musculus REP15 MGD MGI:1913782
Rattus norvegicus REP15 RGD RGD:1562899
Felis catus REP15 VGNC VGNC:64571
Others REP15 NCBI