SC-VC-PAB-N-Me-L-Ala-Maytansinol

Name: SC-VC-PAB-N-Me-L-Ala-Maytansinol
Brand: MedChemExpress
SKU: HY-148528
Rating: 4.5 (1 reviews)

Cat. No.: HY-148528 Purity: 98.16%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

SC-VC-PAB-N-Me-L-Ala-Maytansinol (compound B1) can be used to synthesis MCC-Maytansinoid A. SC-VC-PAB-N-Me-L-Ala-Maytansinol can be used as a control compound for the cancer research.

For research use only. We do not sell to patients.

SC-VC-PAB-N-Me-L-Ala-Maytansinol Chemical Structure

CAS No. : 2226467-76-9

Size	Price	Stock	Quantity
1 mg	USD 520	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1450	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 2400	Get quote	Estimated Time of Arrival: December 31
25 mg	USD 5200	Get quote	Estimated Time of Arrival: December 31
50 mg	USD 8200	Get quote	Estimated Time of Arrival: December 31
100 mg	USD 12800	Get quote	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

SC-VC-PAB-N-Me-L-Ala-Maytansinol (compound B1) can be used to synthesis MCC-Maytansinoid A. SC-VC-PAB-N-Me-L-Ala-Maytansinol can be used as a control compound for the cancer research^[1].

Molecular Weight

1365.91

Formula

C₆₅H₈₉ClN₁₀O₂₀

CAS No.

2226467-76-9

Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@@]([C@@H]([C@]3([H])C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(CCN(C)C(OCC5=CC=C(C=C5)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCC(ON6C(CCC6=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=C(C(OC)=C4)Cl)\C)OC)(NC(O3)=O)O)C)([H])O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (73.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7321 mL	3.6606 mL	7.3211 mL
5 mM	0.1464 mL	0.7321 mL	1.4642 mL
10 mM	0.0732 mL	0.3661 mL	0.7321 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (1.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (1.83 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.16%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (251 KB) HNMR (427 KB) RP-HPLC (266 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. ANDREEV JULIAN, et al. BISPECIFIC ANTIGEN BINDING MOLECULES THAT BIND HER2, AND METHODS OF USE THEREOF. WO2021174113. 2021.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.7321 mL	3.6606 mL	7.3211 mL	18.3028 mL
	5 mM	0.1464 mL	0.7321 mL	1.4642 mL	3.6606 mL
	10 mM	0.0732 mL	0.3661 mL	0.7321 mL	1.8303 mL
	15 mM	0.0488 mL	0.2440 mL	0.4881 mL	1.2202 mL
	20 mM	0.0366 mL	0.1830 mL	0.3661 mL	0.9151 mL
	25 mM	0.0293 mL	0.1464 mL	0.2928 mL	0.7321 mL
	30 mM	0.0244 mL	0.1220 mL	0.2440 mL	0.6101 mL
	40 mM	0.0183 mL	0.0915 mL	0.1830 mL	0.4576 mL
	50 mM	0.0146 mL	0.0732 mL	0.1464 mL	0.3661 mL
	60 mM	0.0122 mL	0.0610 mL	0.1220 mL	0.3050 mL