BRMS1 - BRMS1 transcriptional repressor and anoikis regulator Gene

Homo sapiens

Gene ID: 25855 | Gene type: protein coding

About BRMS1

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,337,339-66,345,104 (from NCBI)

This gene has 9 transcripts (splice variants), 178 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 18.9), testis (RPKM 16.4) and 25 other tissues.

Summary

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast Cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

BRMS1 Products(2)

mRNA	Protein	Name
NM_001024957.2	NP_001020128.1	breast cancer metastasis-suppressor 1 isoform 2
NM_015399.4	NP_056214.1	breast cancer metastasis-suppressor 1 isoform 1

BRMS1 Protein Structure

Sds3

0
100
200
246 a.a.

Protein Preferred Names

Protein Names

breast cancer metastasis-suppressor 1

breast cancer metastasis suppressor 1

Related Diseases

Diseases

Alias

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145946	BRM/BRG1 ATP Inhibitor-2	Inhibitor	98.44%	Unkown
HY-148373	BRM/BRG1 ATP Inhibitor-3	Inhibitor	/	Unkown
HY-148374	BRM/BRG1 ATP Inhibitor-4	Inhibitor	/	Unkown
HY-RS01626	BRMS1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	BRMS1	VGNC	VGNC:60178
Canis familiaris	BRMS1	VGNC	VGNC:54777
Bos taurus	BRMS1	VGNC	VGNC:54781
Rattus norvegicus	BRMS1	RGD	RGD:1311057
Mus musculus	BRMS1	MGD	MGI:2388804
Macaca mulatta	BRMS1	VGNC	VGNC:70334

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