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Cat. No.: HY-148374

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BRM/BRG1 ATP Inhibitor-4

BRM/BRG1 ATP Inhibitor-4 is a BRG1/BRM inhibitor. BRM/BRG1 ATP Inhibitor-4 can be used for the research of cancers and BAF complex-related disorders.

For research use only. We do not sell to patients.

CAS No.: 2422030-94-0
Formula: C₂₅H₃₂N₆O₃S
Molecular Weight:496.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

BRM/BRG1 ATP Inhibitor-4 Chemical Structure

CAS No.: 2422030-94-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

BRM/BRG1 ATP Inhibitor-4 is a BRG1/BRM inhibitor. BRM/BRG1 ATP Inhibitor-4 can be used for the research of cancers and BAF complex-related disorders^[1].

All SWI/SNF Complex Isoforms :

In Vivo

BRM/BRG1 ATP Inhibitor-4 (QD; 5, 15, 50 mg/kg) leds to tumor growth inhibition in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Nude mice^[1]
Dosage:

5, 15, 50 mg/kg
Administration:

QD
Result:

Inhibited tumor growth and the size of tumors in mice engrafted with uveal melanoma cell lines.

Chemical Information

CAS No. 2422030-94-0
Molecular Weight 496.62
Formula C₂₅H₃₂N₆O₃S
SMILES

O=C(C1=CN(C=C1)C(C)(C)C)NCC(NC2=NC(C3=CC=CC(N4C[C@@H](O[C@@H](C4)C)C)=N3)=CS2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kevin J. Wilson, et al. Compounds and uses thereof. Patent. WO2021155320A1.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References

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BRM/BRG1 ATP Inhibitor-4

All SWI/SNF Complex Isoforms