SMARCE1 - SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 Gene
Also Known as CSS5; BAF57
Species: Homo sapiens
About SMARCE1
This gene has 51 transcripts (splice variants), 248 orthologues, 20 paralogues and is associated with 63 phenotypes. Ubiquitous expression in endometrium (RPKM 61.3), ovary (RPKM 41.8) and 25 other tissues.
Summary
The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart. [provided by RefSeq, Jul 2008]
SMARCE1 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_003079.5 | NP_003070.3 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables N-acetyltransferase activity |
IDA
IDA: Inferred from direct assay
|
12192000 | GOA |
| enables nuclear receptor binding |
IPI
IPI: Inferred from physical interaction
|
17363140 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
12192000 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in chromatin remodeling |
IDA
IDA: Inferred from direct assay
|
11726552 | GOA |
| involved in negative regulation of DNA-templated transcription |
IDA
IDA: Inferred from direct assay
|
12192000 | GOA |
| involved in nucleosome disassembly |
IDA
IDA: Inferred from direct assay
|
8895581 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of SWI/SNF complex |
IDA
IDA: Inferred from direct assay
|
8804307 | GOA |
SMARCE1 Protein Structure
HMG_box: HMG (high mobility group) box (66 - 133)
- 0
- 100
- 200
- 300
- 411 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 |
|
SMARCE1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
SMARCE1 | Q969G3 | CCDC136 | Homo sapiens | Q96JN2-2 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | KRT40 | Homo sapiens | Q6A162 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | KRT40 | Homo sapiens | Q6A162 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | KRT40 | Homo sapiens | Q6A162 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | KRTAP10-8 | Homo sapiens | P60410 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | KRTAP10-8 | Homo sapiens | P60410 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | KRTAP10-9 | Homo sapiens | P60411 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | CCHCR1 | Homo sapiens | Q8TD31-3 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | CCHCR1 | Homo sapiens | Q8TD31-3 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | AMOTL2 | Homo sapiens | Q9Y2J4-4 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | KRT37 | Homo sapiens | O76014 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | KRT37 | Homo sapiens | O76014 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | KRT34 | Homo sapiens | O76011 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | KRT34 | Homo sapiens | O76011 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | KRT35 | Homo sapiens | Q92764 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | KRT35 | Homo sapiens | Q92764 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | TFIP11 | Homo sapiens | Q9UBB9 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | TFIP11 | Homo sapiens | Q9UBB9 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | TFIP11 | Homo sapiens | Q9UBB9 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | TFIP11 | Homo sapiens | Q9UBB9 | 31515488 | |
|
Intra
|
SMARCE1 | Q969G3 | TFIP11 | Homo sapiens | Q9UBB9 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | TFIP11 | Homo sapiens | Q9UBB9 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | TFIP11 | Homo sapiens | Q9UBB9 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | MTUS2 | Homo sapiens | Q5JR59-3 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | MTUS2 | Homo sapiens | Q5JR59-3 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | CEP63 | Homo sapiens | Q96MT8-3 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | CEP63 | Homo sapiens | Q96MT8-3 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | CEP63 | Homo sapiens | Q96MT8-3 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | CDR2 | Homo sapiens | Q01850 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | CDR2 | Homo sapiens | Q01850 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | CDR2 | Homo sapiens | Q01850 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | CDR2 | Homo sapiens | Q01850 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | CDR2 | Homo sapiens | Q01850 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | KRT39 | Homo sapiens | Q6A163 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | KRT39 | Homo sapiens | Q6A163 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | KRTAP1-1 | Homo sapiens | Q07627 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | KRTAP1-1 | Homo sapiens | Q07627 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | DISC1 | Homo sapiens | Q9NRI5-2 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | DISC1 | Homo sapiens | Q9NRI5-2 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | DISC1 | Homo sapiens | Q9NRI5-2 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | IFT74 | Homo sapiens | Q96LB3-2 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | TEX12 | Homo sapiens | Q9BXU0 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | TEX12 | Homo sapiens | Q9BXU0 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | TEX12 | Homo sapiens | Q9BXU0 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | CCDC183 | Homo sapiens | G5E9W6 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | CCDC183 | Homo sapiens | G5E9W6 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | EXOC4 | Homo sapiens | Q96A65-2 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | EXOC4 | Homo sapiens | Q96A65-2 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | EXOC4 | Homo sapiens | Q96A65-2 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | FAM217B | Homo sapiens | Q9NTX9 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | FAM217B | Homo sapiens | Q9NTX9 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | FAM217B | Homo sapiens | Q9NTX9 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | KIFC3 | Homo sapiens | Q9BVG8 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | TRIM54 | Homo sapiens | Q9BYV2 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | TRIM54 | Homo sapiens | Q9BYV2 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | KRTAP6-3 | Homo sapiens | Q3LI67 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | KRTAP6-3 | Homo sapiens | Q3LI67 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | MIPOL1 | Homo sapiens | Q8TD10 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | MIPOL1 | Homo sapiens | Q8TD10 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | MIPOL1 | Homo sapiens | Q8TD10 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | MIPOL1 | Homo sapiens | Q8TD10 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | CCDC172 | Homo sapiens | P0C7W6 | 31515488 | |
|
Intra
|
SMARCE1 | Q969G3 | CCDC172 | Homo sapiens | P0C7W6 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | VPS52 | Homo sapiens | Q8N1B4 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | VPS52 | Homo sapiens | Q8N1B4 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | KRT27 | Homo sapiens | Q7Z3Y8 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | KRT27 | Homo sapiens | Q7Z3Y8 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | IFT88 | Homo sapiens | Q13099 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | IFT88 | Homo sapiens | Q13099 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | KRT16 | Homo sapiens | P08779 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | KRT16 | Homo sapiens | P08779 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | PSMC6 | Homo sapiens | P62333 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | PSMC6 | Homo sapiens | P62333 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | TXLNA | Homo sapiens | P40222 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | TXLNA | Homo sapiens | P40222 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | CYSRT1 | Homo sapiens | A8MQ03 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | MED4 | Homo sapiens | Q9NPJ6 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | MED4 | Homo sapiens | Q9NPJ6 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | MED4 | Homo sapiens | Q9NPJ6 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | ING5 | Homo sapiens | Q8WYH8 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | FSD2 | Homo sapiens | A1L4K1 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | FSD2 | Homo sapiens | A1L4K1 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | GOLGA6L9 | Homo sapiens | A6NEM1 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | GOLGA6L9 | Homo sapiens | A6NEM1 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | GOLGA2 | Homo sapiens | Q08379 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | GOLGA2 | Homo sapiens | Q08379 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | GOLGA2 | Homo sapiens | Q08379 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | GOLGA2 | Homo sapiens | Q08379 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | ARID2 | Homo sapiens | Q68CP9 | 33961781 | |
|
Intra
|
SMARCE1 | Q969G3 | ARID2 | Homo sapiens | Q68CP9 | 15985610 | |
|
Intra
|
SMARCE1 | Q969G3 | ARID2 | Homo sapiens | Q68CP9 | 24981860 | |
|
Intra
|
SMARCE1 | Q969G3 | TRIP10 | Homo sapiens | Q15642-2 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | TRIP10 | Homo sapiens | Q15642-2 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | KRT14 | Homo sapiens | P02533 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | KRT14 | Homo sapiens | P02533 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | STX11 | Homo sapiens | O75558 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | STX11 | Homo sapiens | O75558 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | BRMS1 | Homo sapiens | Q9HCU9 | 16919237 | |
|
Intra
|
SMARCE1 | Q969G3 | GRIPAP1 | Homo sapiens | Q4V328 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | GRIPAP1 | Homo sapiens | Q4V328 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | EXOC7 | Homo sapiens | Q9UPT5 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | EXOC7 | Homo sapiens | Q9UPT5 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | RINT1 | Homo sapiens | Q6NUQ1 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | RINT1 | Homo sapiens | Q6NUQ1 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | KRT15 | Homo sapiens | P19012 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | KRT15 | Homo sapiens | P19012 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | CEP70 | Homo sapiens | Q8NHQ1 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | CEP70 | Homo sapiens | Q8NHQ1 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | CEP70 | Homo sapiens | Q8NHQ1 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | USHBP1 | Homo sapiens | Q8N6Y0 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | TRIP10 | Homo sapiens | Q15642 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | CEP63 | Homo sapiens | Q96MT8 | 21516116 | |
|
Intra
|
SMARCE1 | Q969G3 | CEP63 | Homo sapiens | Q96MT8 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | CEP63 | Homo sapiens | Q96MT8 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | KRT19 | Homo sapiens | P08727 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | KRT19 | Homo sapiens | P08727 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | MTUS2 | Homo sapiens | Q5JR59 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | MTUS2 | Homo sapiens | Q5JR59 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | MTUS2 | Homo sapiens | Q5JR59 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | CEP170P1 | Homo sapiens | Q96L14 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | CEP170P1 | Homo sapiens | Q96L14 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | AMOTL2 | Homo sapiens | Q9Y2J4 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | AMOTL2 | Homo sapiens | Q9Y2J4 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | AMOTL2 | Homo sapiens | Q9Y2J4 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | MEOX2 | Homo sapiens | P50222 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | MRFAP1L1 | Homo sapiens | Q96HT8 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | RALBP1 | Homo sapiens | Q15311 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | RALBP1 | Homo sapiens | Q15311 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | RALBP1 | Homo sapiens | Q15311 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | RALBP1 | Homo sapiens | Q15311 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | RALBP1 | Homo sapiens | Q15311 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | JAKMIP2 | Homo sapiens | Q96AA8 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | JAKMIP2 | Homo sapiens | Q96AA8 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | NOTCH2NLA | Homo sapiens | Q7Z3S9 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | NOTCH2NLA | Homo sapiens | Q7Z3S9 | 25416956 | |
|
Intra
|
SMARCE1 | Q969G3 | KRT31 | Homo sapiens | Q15323 | 32296183 | |
|
Intra
|
SMARCE1 | Q969G3 | KRT31 | Homo sapiens | Q15323 | 32296183 |
SMARCE1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P82365 | Baf57 Antibody (YA2110) | WB, IHC-P, ICC/IF, IP | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Meningioma, Familial |
|
|
| Coffin-Siris Syndrome 5 |
|
|
| Facial Cleft |
|
|
| Coffin-Siris Syndrome 1 |
|
|
| Bap1 Tumor Predisposition Syndrome |
|
|
| Inherited Cancer-Predisposing Syndrome |
|
|
| Clear Cell Meningioma |
|
|
| Spinal Meningioma |
|
|
| Spinal Canal And Spinal Cord Meningioma |
|
|
| Spinal Cancer |
|
|
| Autosomal Dominant Intellectual Developmental Disorder |
|
|
| Parasagittal Meningioma |
|
|
| Clark-Baraitser Syndrome |
|
|
| Angiomatous Meningioma |
|
|
| Hypertrichosis |
|
|
| Rhabdoid Meningioma |
|
|
| Childhood Meningioma |
|
|
| Neurilemmomatosis |
|
|
| Cerebral Convexity Meningioma |
|
|
| Cerebral Falx Meningioma |
|
|
| Skull Base Meningioma |
|
|
| Skull Base Cancer |
|
|
| Meningothelial Meningioma |
|
|
| Anterior Cranial Fossa Meningioma |
|
|
| Secretory Meningioma |
|
|
| Coffin-Siris Syndrome 6 |
|
|
| Olfactory Groove Meningioma |
|
|
| Solitary Fibrous Tumor/Hemangiopericytoma |
|
|
| Brain Meningioma |
|
|
| Transitional Meningioma |
|
|
| Intraventricular Meningioma |
|
|
| Cerebellopontine Angle Meningioma |
|
|
| Microcystic Meningioma |
|
|
| Intracranial Meningioma |
|
|
| Sphenoorbital Meningioma |
|
|
| Cavernous Sinus Meningioma |
|
|
| Cerebral Meningioma |
|
|
| Fibrous Meningioma |
|
|
| Adenoid Cystic Carcinoma |
|
|
| Rhabdoid Cancer |
|
|
| Familial Isolated Trichomegaly |
|
|
| Borjeson-Forssman-Lehmann Syndrome |
|
|
| Atypical Teratoid Rhabdoid Tumor |
|
|
| Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation, And Seizures Syndrome |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | SMARCE1 | VGNC | VGNC:34996 |
| Rattus norvegicus | SMARCE1 | RGD | RGD:1304726 |
| Felis catus | SMARCE1 | VGNC | VGNC:99456 |
| Macaca mulatta | SMARCE1 | VGNC | VGNC:97830 |
| Mus musculus | SMARCE1 | MGD | MGI:1927347 |
| Canis familiaris | SMARCE1 | VGNC | VGNC:46540 |
| Others | SMARCE1 | NCBI |