EXOC7 - exocyst complex component 7 Gene
Also Known as BLOM4; EX070; EXO70; EXOC1; 2-5-3p; Exo70p; NEDSEBA; YJL085W
Species: Homo sapiens
About EXOC7
This gene has 21 transcripts (splice variants), 207 orthologues and is associated with 1 phenotype. Ubiquitous expression in prostate (RPKM 23.4), brain (RPKM 22.0) and 25 other tissues.
Summary
The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Nov 2011]
EXOC7 Products (10)
| mRNA | Protein | Name |
|---|---|---|
| NM_001013839.4 | NP_001013861.1 | exocyst complex component 7 isoform 1 |
| NM_001145297.4 | NP_001138769.1 | exocyst complex component 7 isoform 4 |
| NM_001145298.4 | NP_001138770.1 | exocyst complex component 7 isoform 5 |
| NM_001145299.4 | NP_001138771.1 | exocyst complex component 7 isoform 6 |
| NM_001282313.2 | NP_001269242.1 | exocyst complex component 7 isoform 3 |
| NM_001282314.2 | NP_001269243.1 | exocyst complex component 7 isoform 7 |
| NM_001375974.1 | NP_001362903.1 | exocyst complex component 7 isoform 8 |
| NM_001375975.1 | NP_001362904.1 | exocyst complex component 7 isoform 9 |
| NM_001375976.1 | NP_001362905.1 | exocyst complex component 7 isoform 10 |
| NM_015219.5 | NP_056034.2 | exocyst complex component 7 isoform 2 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
15705715 | GOA |
| enables protein-macromolecule adaptor activity |
IDA
IDA: Inferred from direct assay
|
16148947 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in positive regulation of mitotic cytokinetic process |
IDA
IDA: Inferred from direct assay
|
16148947 | GOA |
| involved in regulation of entry of bacterium into host cell |
IMP
IMP: Inferred from mutant phenotype
|
20579884 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in centriolar satellite |
IDA
IDA: Inferred from direct assay
|
18000879 | GOA |
| located in microtubule organizing center |
IDA
IDA: Inferred from direct assay
|
18000879 | GOA |
| is active in midbody |
IDA
IDA: Inferred from direct assay
|
16148947 | GOA |
EXOC7 Protein Structure
Exo70: Exo70 exocyst complex subunit (364 - 730)
- 0
- 200
- 400
- 600
- 735 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
exocyst complex component 7 |
|
EXOC7 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
EXOC7 | Q9UPT5 | SSC5D | Homo sapiens | A1L4H1 | 25416956 | |
|
Intra
|
EXOC7 | Q9UPT5 | SSC5D | Homo sapiens | A1L4H1 | 25416956 | |
|
Intra
|
EXOC7 | Q9UPT5 | SMARCE1 | Homo sapiens | Q969G3 | 25416956 | |
|
Intra
|
EXOC7 | Q9UPT5 | SMARCE1 | Homo sapiens | Q969G3 | 25416956 | |
|
Intra
|
EXOC7 | Q9UPT5 | SMARCE1 | Homo sapiens | Q969G3 | 25416956 | |
|
Intra
|
EXOC7 | Q9UPT5 | KXD1 | Homo sapiens | Q9BQD3 | 16189514 | |
|
Intra
|
EXOC7 | Q9UPT5 | HGS | Homo sapiens | O14964 | 25416956 | |
|
Intra
|
EXOC7 | Q9UPT5 | HGS | Homo sapiens | O14964 | 25416956 | |
|
Intra
|
EXOC7 | Q9UPT5 | HGS | Homo sapiens | O14964 | 25416956 | |
|
Intra
|
EXOC7 | Q9UPT5 | IFT20 | Homo sapiens | Q8IY31 | 16189514 | |
|
Intra
|
EXOC7 | Q9UPT5 | IFT20 | Homo sapiens | Q8IY31 | 25416956 | |
|
Intra
|
EXOC7 | Q9UPT5 | IFT20 | Homo sapiens | Q8IY31 | 25416956 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Neurodevelopmental Disorder With Seizures And Brain Atrophy |
|
|
| Bardet-Biedl Syndrome |
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | EXOC7 | VGNC | VGNC:28652 |
| Felis catus | EXOC7 | VGNC | VGNC:62004 |
| Mus musculus | EXOC7 | MGD | MGI:1859270 |
| Rattus norvegicus | EXOC7 | RGD | RGD:620236 |
| Canis familiaris | EXOC7 | VGNC | VGNC:40518 |
| Macaca mulatta | EXOC7 | VGNC | VGNC:72319 |
| Others | EXOC7 | NCBI |