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SSC5D - scavenger receptor cysteine rich family member with 5 domains Gene

Also Known as S5D-SRCRB

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 284297

About SSC5D

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:55,488,436-55,519,099 (from NCBI)

This gene has 5 transcripts (splice variants), 397 orthologues and 15 paralogues. Broad expression in gall bladder (RPKM 7.3), endometrium (RPKM 6.2) and 21 other tissues.

Summary

Predicted to enable fibronectin binding activity; laminin binding activity; and scavenger receptor activity. Predicted to be involved in defense response; detection of Bacterial lipoprotein; and negative regulation of interleukin-8 production. Predicted to act upstream of or within regulation of interleukin-8 production. Predicted to be located in collagen-containing extracellular matrix. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

SSC5D Products (2)

mRNA	Protein	Name
NM_001144950.2	NP_001138422.1	soluble scavenger receptor cysteine-rich domain-containing protein SSC5D isoform 1 precursor
NM_001195267.2	NP_001182196.1	soluble scavenger receptor cysteine-rich domain-containing protein SSC5D isoform 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SSC5D Protein Structure

SRCR

0
300
600
900
1200
1500
1573 a.a.

Protein Preferred Names	Protein Names
soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	scavenger receptor cysteine rich domain containing (5 domains)

SSC5D Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SSC5D	A1L4H1	NECAB2	Homo sapiens	Q7Z6G3-2	Validated Y2H	32296183
Intra	SSC5D	A1L4H1	NECAB2	Homo sapiens	Q7Z6G3-2	Validated Y2H	25416956
Intra	SSC5D	A1L4H1	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Prey Pooling	32296183
Intra	SSC5D	A1L4H1	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Array	32296183
Intra	SSC5D	A1L4H1	SEC23IP	Homo sapiens	Q9Y6Y8	Validated Y2H	25416956
Intra	SSC5D	A1L4H1	SEC23IP	Homo sapiens	Q9Y6Y8	Y2H Prey Pooling	25416956
Intra	SSC5D	A1L4H1	SEC23IP	Homo sapiens	Q9Y6Y8	Validated Y2H	32296183
Intra	SSC5D	A1L4H1	SEC23IP	Homo sapiens	Q9Y6Y8	Y2H Prey Pooling	32296183
Intra	SSC5D	A1L4H1	SEC23IP	Homo sapiens	Q9Y6Y8	Y2H Array	32296183
Intra	SSC5D	A1L4H1	HAUS1	Homo sapiens	Q96CS2	Validated Y2H	32296183
Intra	SSC5D	A1L4H1	HAUS1	Homo sapiens	Q96CS2	Y2H Array	32296183
Intra	SSC5D	A1L4H1	HAUS1	Homo sapiens	Q96CS2	Y2H Prey Pooling	32296183
Intra	SSC5D	A1L4H1	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	SSC5D	A1L4H1	KRT27	Homo sapiens	Q7Z3Y8	Validated Y2H	32296183
Intra	SSC5D	A1L4H1	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	SSC5D	A1L4H1	NUP62	Homo sapiens	P37198	Validated Y2H	25416956
Intra	SSC5D	A1L4H1	NUP62	Homo sapiens	P37198	Y2H Prey Pooling	32296183
Intra	SSC5D	A1L4H1	NUP62	Homo sapiens	P37198	Validated Y2H	32296183
Intra	SSC5D	A1L4H1	NUP62	Homo sapiens	P37198	Y2H Array	32296183
Intra	SSC5D	A1L4H1	TRAF1	Homo sapiens	Q13077	Y2H Array	25416956
Intra	SSC5D	A1L4H1	MED29	Homo sapiens	Q9NX70	Validated Y2H	32296183
Intra	SSC5D	A1L4H1	MED29	Homo sapiens	Q9NX70	Y2H Array	32296183
Intra	SSC5D	A1L4H1	MED21	Homo sapiens	Q13503	Validated Y2H	32296183
Intra	SSC5D	A1L4H1	MED21	Homo sapiens	Q13503	Y2H Array	32296183
Intra	SSC5D	A1L4H1	MED21	Homo sapiens	Q13503	Y2H Prey Pooling	25416956
Intra	SSC5D	A1L4H1	MED21	Homo sapiens	Q13503	Y2H Prey Pooling	32296183
Intra	SSC5D	A1L4H1	MED11	Homo sapiens	Q9P086	Y2H Array	32296183
Intra	SSC5D	A1L4H1	MED11	Homo sapiens	Q9P086	Y2H Prey Pooling	32296183
Intra	SSC5D	A1L4H1	MED11	Homo sapiens	Q9P086	Validated Y2H	32296183
Intra	SSC5D	A1L4H1	DTNBP1	Homo sapiens	Q96EV8	Validated Y2H	25416956
Intra	SSC5D	A1L4H1	BLOC1S2	Homo sapiens	Q6QNY1	Validated Y2H	32296183
Intra	SSC5D	A1L4H1	BLOC1S2	Homo sapiens	Q6QNY1	Y2H Array	32296183
Intra	SSC5D	A1L4H1	BLOC1S2	Homo sapiens	Q6QNY1	Y2H Prey Pooling	32296183
Intra	SSC5D	A1L4H1	EXOC7	Homo sapiens	Q9UPT5-1	Y2H Prey Pooling	32296183
Intra	SSC5D	A1L4H1	EXOC7	Homo sapiens	Q9UPT5-1	Validated Y2H	32296183
Intra	SSC5D	A1L4H1	EXOC7	Homo sapiens	Q9UPT5-1	Y2H Array	32296183
Intra	SSC5D	A1L4H1	TCEA2	Homo sapiens	Q15560	Validated Y2H	32296183
Intra	SSC5D	A1L4H1	PIN1	Homo sapiens	Q13526	Validated Y2H	32296183
Intra	SSC5D	A1L4H1	EXOC7	Homo sapiens	Q9UPT5	Y2H Prey Pooling	25416956
Intra	SSC5D	A1L4H1	SDCBP	Homo sapiens	O00560	Validated Y2H	32296183
Intra	SSC5D	A1L4H1	SKA1	Homo sapiens	Q96BD8	Y2H Prey Pooling	32296183
Intra	SSC5D	A1L4H1	SKA1	Homo sapiens	Q96BD8	Y2H Array	32296183
Intra	SSC5D	A1L4H1	SKA1	Homo sapiens	Q96BD8	Validated Y2H	32296183
Intra	SSC5D	A1L4H1	CEP170P1	Homo sapiens	Q96L14	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Nasal Type Extranodal Nk/T-Cell Lymphoma	Extranodal Nasal Nk/T Cell Lymphoma Angiocentric T-Cell Lymphoma Lethal Midline Granuloma Nk/T-Cell Lymphoma Nktcl Nasal T/Natural Killer-Cell Lymphoma Granuloma, Lethal Midline Nasal And Nasal-Type Nk/T-Cell Lymphoma
Adenoiditis	Chronic Adenoiditis
Vitreous Detachment	Posterior Vitreous Detachment Vitreous Syneresis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13808	SSC5D Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21055	Ssc5d Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27573	Ssc5d Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SSC5D	VGNC	VGNC:53993
Felis catus	SSC5D	VGNC	VGNC:82391
Mus musculus	SSC5D	MGD	MGI:3606211
Rattus norvegicus	SSC5D	RGD	RGD:1565772
Bos taurus	SSC5D	VGNC	VGNC:35310
Others	SSC5D	NCBI