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SKA1 - spindle and kinetochore associated complex subunit 1 Gene

Also Known as C18orf24

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 220134

About SKA1

Cytogenetic location: 18q21.1 Genomic coordinates (GRCh38): 18:50,375,046-50,394,168 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele and 97 orthologues. Biased expression in bone marrow (RPKM 4.0), testis (RPKM 3.1) and 12 other tissues.

Summary

Enables microtubule binding activity. Involved in several processes, including chromosome segregation; mitotic cell cycle; and regulation of microtubule polymerization or depolymerization. Located in spindle microtubule. Part of outer kinetochore. [provided by Alliance of Genome Resources, Apr 2022]

SKA1 Products (2)

mRNA	Protein	Name
NM_001039535.3	NP_001034624.1	spindle and kinetochore-associated protein 1
NM_145060.4	NP_659497.1	spindle and kinetochore-associated protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables microtubule binding	IDA IDA: Inferred from direct assay	19289083	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in attachment of mitotic spindle microtubules to kinetochore	IDA IDA: Inferred from direct assay	29487209	GOA
involved in attachment of mitotic spindle microtubules to kinetochore	IMP IMP: Inferred from mutant phenotype	36592928	GOA
involved in metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	22371557	GOA
involved in mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	19289083	GOA
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	28495837	GOA
involved in mitotic sister chromatid segregation	IMP IMP: Inferred from mutant phenotype	17093495	GOA
involved in negative regulation of mitotic spindle assembly checkpoint signaling	IMP IMP: Inferred from mutant phenotype	26981768	GOA
involved in positive regulation of microtubule polymerization	IDA IDA: Inferred from direct assay	27225956	GOA
involved in regulation of microtubule polymerization or depolymerization	IDA IDA: Inferred from direct assay	19289083	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of SKA complex	IDA IDA: Inferred from direct assay	31804178	GOA
located in centrosome	IDA IDA: Inferred from direct assay	26981768	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	24413531	GOA
located in kinetochore	IPI IPI: Inferred from physical interaction	21633384	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	26981768	GOA
located in mitotic spindle microtubule	IDA IDA: Inferred from direct assay	27225956	GOA
part of outer kinetochore	IDA IDA: Inferred from direct assay	17093495	GOA
located in spindle microtubule	IDA IDA: Inferred from direct assay	17093495	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SKA1 Protein Structure

SKA1

0
100
200
255 a.a.

Protein Preferred Names	Protein Names
spindle and kinetochore-associated protein 1	spindle and KT (kinetochore) associated 1

SKA1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SKA1	Q96BD8	CCDC196	Homo sapiens	A0A1B0GWI1	Y2H Array	32296183
Intra	SKA1	Q96BD8	CCDC196	Homo sapiens	A0A1B0GWI1	Y2H Prey Pooling	32296183
Intra	SKA1	Q96BD8	SKA3	Homo sapiens	Q8IX90	Y2H Array	32296183
Intra	SKA1	Q96BD8	SKA3	Homo sapiens	Q8IX90	Anti Tag CoIP	26496610
Intra	SKA1	Q96BD8	SKA3	Homo sapiens	Q8IX90	Y2H Array	31515488
Intra	SKA1	Q96BD8	SKA3	Homo sapiens	Q8IX90	GMS	19360002
Intra	SKA1	Q96BD8	SKA3	Homo sapiens	Q8IX90	Y2H Prey Pooling	32296183
Intra	SKA1	Q96BD8	SKA2	Homo sapiens	Q8WVK7	Anti Bait CoIP	17093495
Intra	SKA1	Q96BD8	SKA2	Homo sapiens	Q8WVK7	Y2H	17093495
Intra	SKA1	Q96BD8	SKA2	Homo sapiens	Q8WVK7	Imaging	17093495
Intra	SKA1	Q96BD8	SKA2	Homo sapiens	Q8WVK7	GMS	19360002
Intra	SKA1	Q96BD8	SKA2	Homo sapiens	Q8WVK7	Anti Tag CoIP	26496610
Intra	SKA1	Q96BD8	FAM9C	Homo sapiens	Q8IZT9	Y2H Prey Pooling	32296183
Intra	SKA1	Q96BD8	FAM9C	Homo sapiens	Q8IZT9	Y2H Array	32296183
Intra	SKA1	Q96BD8	SNAPIN	Homo sapiens	O95295	Y2H Prey Pooling	32296183
Intra	SKA1	Q96BD8	SNAPIN	Homo sapiens	O95295	Y2H Array	32296183
Intra	SKA1	Q96BD8	PSMC5	Homo sapiens	P62195	Anti Tag CoIP	26496610
Intra	SKA1	Q96BD8	BLOC1S6	Homo sapiens	Q9UL45	Validated Y2H	25416956
Intra	SKA1	Q96BD8	BLOC1S6	Homo sapiens	Q9UL45	Validated Y2H	32296183
Intra	SKA1	Q96BD8	SYCE1	Homo sapiens	Q8N0S2	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Serous Labyrinthitis	Acute Serous Labyrinthitis
Ovary Serous Adenocarcinoma	Malignant Ovarian Serous Tumor Serous Carcinoma Of Ovary
Acute Poststreptococcal Glomerulonephritis	Post-Streptococcal Glomerulonephritis Acute Post-Streptococcal Glomerulonephritis
Filippi Syndrome	Scott Craniodigital Syndrome With Mental Retardation Type 1 Syndactyly-Microcephaly-Intellectual Disability Syndrome FLPIS Scott Bryant Graham Syndrome Craniodigital-Intellectual Disability Syndrome Scott Craniodigital Syndrome Scott-Bryant-Graham Syndrome Syndactyly, Type I, With Microcephaly And Mental Retardation Syndactyly Type I With Microcephaly And Intellectual Disability Unusual Facial Appearance, Microcephaly, Growth And Intellectual Disability And Syndactyly Craniodigital Syndrome With Intellectual Disability Craniodigital Syndrome-Intellectual Disability Syndrome Craniodigital Syndrome-Intellectual Disability, Scott Type Intellectual Disability-Craniodigital Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12964	SKA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22326	Ska1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28848	Ska1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SKA1	RGD	RGD:1310784
Bos taurus	SKA1	VGNC	VGNC:34643
Canis familiaris	SKA1	VGNC	VGNC:46193
Felis catus	SKA1	VGNC	VGNC:65167
Mus musculus	SKA1	MGD	MGI:1913718
Macaca mulatta	SKA1	VGNC	VGNC:77577
Others	SKA1	NCBI