SKA2 - spindle and kinetochore associated complex subunit 2 Gene

Homo sapiens

Also known as FAM33A

Gene ID: 348235 | Gene type: protein coding

About SKA2

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:59,109,857-59,155,186 (from NCBI)

This gene has 10 transcripts (splice variants) and 230 orthologues. Ubiquitous expression in brain (RPKM 9.5), thyroid (RPKM 8.8) and 25 other tissues.

Summary

Enables microtubule binding activity. Involved in several processes, including chromosome segregation; mitotic cell cycle; and regulation of microtubule polymerization or depolymerization. Located in spindle microtubule. Part of outer kinetochore. [provided by Alliance of Genome Resources, Apr 2022]

SKA2 Products(3)

mRNA	Protein	Name
NM_001100595.2	NP_001094065.1	spindle and kinetochore-associated protein 2 isoform 2
NM_001330399.2	NP_001317328.1	spindle and kinetochore-associated protein 2 isoform 3
NM_182620.4	NP_872426.1	spindle and kinetochore-associated protein 2 isoform 1

Protein Preferred Names

Protein Names

spindle and kinetochore-associated protein 2

family with sequence similarity 33, member A

Related Diseases

Diseases

Alias

Mulibrey Nanism

MUL	Muscle-Liver-Brain-Eye Nanism
Pericardial Constriction And Growth Failure	Perheentupa Syndrome
Mulibrey Growth Disorder	Mulibrey Nanism Syndrome
Pericardial Constriction With Growth Failure	Nanism Mulibrey

Acute Poststreptococcal Glomerulonephritis

Post-Streptococcal Glomerulonephritis

Acute Post-Streptococcal Glomerulonephritis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12965	SKA2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SKA2	VGNC	VGNC:34644
Canis familiaris	SKA2	VGNC	VGNC:46194
Macaca mulatta	SKA2	VGNC	VGNC:104651
Mus musculus	SKA2	MGD	MGI:1913390
Rattus norvegicus	SKA2	RGD	RGD:1307084