SKA3 - spindle and kinetochore associated complex subunit 3 Gene

Also Known as RAMA1; C13orf3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 221150

About SKA3

Cytogenetic location: 13q12.11 Genomic coordinates (GRCh38): 13:21,153,595-21,176,552 (from NCBI)

This gene has 7 transcripts (splice variants) and 195 orthologues. Biased expression in testis (RPKM 4.8), bone marrow (RPKM 3.0) and 13 other tissues.

Summary

This gene encodes a component of the spindle and kinetochore-associated protein complex that regulates microtubule attachment to the kinetochores during Mitosis. The encoded protein localizes to the outer kinetechore and may be required for normal chromosome segregation and cell division. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

SKA3 Products (2)

mRNA Protein Name
NM_001166017.2 NP_001159489.1 spindle and kinetochore-associated protein 3 isoform 2
NM_145061.6 NP_659498.4 spindle and kinetochore-associated protein 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables microtubule binding IDA
IDA: Inferred from direct assay
29487209 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19289083 GOA
Biological Process GO Annotation Evidence References Source
involved in attachment of mitotic spindle microtubules to kinetochore IDA
IDA: Inferred from direct assay
29487209 GOA
involved in attachment of mitotic spindle microtubules to kinetochore IMP
IMP: Inferred from mutant phenotype
28479321 GOA
involved in metaphase chromosome alignment IMP
IMP: Inferred from mutant phenotype
22371557 GOA
involved in mitotic metaphase chromosome alignment IPI
IPI: Inferred from physical interaction
28495837 GOA
involved in mitotic sister chromatid segregation IMP
IMP: Inferred from mutant phenotype
19289083 GOA
involved in negative regulation of mitotic spindle assembly checkpoint signaling IMP
IMP: Inferred from mutant phenotype
19646878 GOA
involved in regulation of microtubule polymerization or depolymerization IDA
IDA: Inferred from direct assay
19289083 GOA
Cellular Component GO Annotation Evidence References Source
part of SKA complex IDA
IDA: Inferred from direct assay
31804178 GOA
located in centrosome IDA
IDA: Inferred from direct assay
19646878 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
20813266 GOA
located in kinetochore IPI
IPI: Inferred from physical interaction
21633384 GOA
located in mitotic spindle IDA
IDA: Inferred from direct assay
19646878 GOA
part of outer kinetochore IDA
IDA: Inferred from direct assay
19289083 GOA
located in spindle microtubule IDA
IDA: Inferred from direct assay
19289083 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

spindle and kinetochore-associated protein 3

SKA3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SKA3 Q8IX90 SKA1 Homo sapiens Q96BD8
Anti Tag CoIP
33961781
Intra
SKA3 Q8IX90 SKA1 Homo sapiens Q96BD8
Anti Tag CoIP
28514442
Intra
SKA3 Q8IX90 SKA1 Homo sapiens Q96BD8
Validated Y2H
32296183
Intra
SKA3 Q8IX90 SKA1 Homo sapiens Q96BD8
Anti Tag CoIP
26496610
Intra
SKA3 Q8IX90 SKA1 Homo sapiens Q96BD8
IF
19360002
Intra
SKA3 Q8IX90 SKA1 Homo sapiens Q96BD8
Anti Tag CoIP
19360002
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Uterine Adnexa Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12966 SKA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SKA3 VGNC VGNC:65168
Rattus norvegicus SKA3 RGD RGD:1307201
Canis familiaris SKA3 VGNC VGNC:46195
Bos taurus SKA3 VGNC VGNC:34645
Macaca mulatta SKA3 VGNC VGNC:77525
Mus musculus SKA3 MGD MGI:3041235
Others SKA3 NCBI