PSMC5 - proteasome 26S subunit, ATPase 5 Gene

Homo sapiens

Also known as S8; p45; RPT6; SUG1; SUG-1; TBP10; TRIP1; p45/SUG

Gene ID: 5705 | Gene type: protein coding

About PSMC5

Cytogenetic location: 17q23.3 Genomic coordinates (GRCh38): 17:63,827,431-63,832,019 (from NCBI)

This gene has 25 transcripts (splice variants), 222 orthologues, 5 paralogues and is associated with 1 phenotype. Ubiquitous expression in kidney (RPKM 58.1), brain (RPKM 54.9) and 25 other tissues.

Summary

The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in Proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the Thyroid Hormone Receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

PSMC5 Products(2)

mRNA	Protein	Name
NM_001199163.2	NP_001186092.1	26S proteasome regulatory subunit 8 isoform 2
NM_002805.6	NP_002796.4	26S proteasome regulatory subunit 8 isoform 1

PSMC5 Protein Structure

AAA

0
100
200
300
406 a.a.

Protein Preferred Names

Protein Names

26S proteasome regulatory subunit 8

26S protease regulatory subunit 8

Related Diseases

Diseases

Alias

Cockayne Syndrome

Cockayne'S Syndrome	Dwarfism-Retinal Atrophy-Deafness Syndrome
Neill-Dingwall Syndrome	Progeria-Like Syndrome
Progeroid Nanism	Cs

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11315	PSMC5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PSMC5	VGNC	VGNC:69116
Mus musculus	PSMC5	MGD	MGI:105047
Macaca mulatta	PSMC5	VGNC	VGNC:81513
Rattus norvegicus	PSMC5	RGD	RGD:708376
Bos taurus	PSMC5	VGNC	VGNC:33459

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