RORC - RAR related orphan receptor C Gene

Homo sapiens

Also known as TOR; RORG; RZRG; IMD42; NR1F3; RZR-GAMMA

Gene ID: 6097 | Gene type: protein coding

About RORC

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,806,071-151,831,802 (from NCBI)

This gene has 11 transcripts (splice variants), 383 orthologues, 18 paralogues and is associated with 2 phenotypes. Broad expression in liver (RPKM 16.0), thyroid (RPKM 15.9) and 18 other tissues.

Summary

The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RORC Products(4)

mRNA	Protein	Name
NM_001001523.2	NP_001001523.1	nuclear receptor ROR-gamma isoform b
NM_005060.4	NP_005051.2	nuclear receptor ROR-gamma isoform a
XM_006711484.5	XP_006711547.3	nuclear receptor ROR-gamma isoform X2
XM_047427201.1	XP_047283157.1	nuclear receptor ROR-gamma isoform X1

RORC Protein Structure

zf-C4

Hormone_recep

0
100
200
300
400
518 a.a.

Protein Preferred Names

Protein Names

nuclear receptor ROR-gamma

nuclear receptor RZR-gamma	nuclear receptor subfamily 1 group F member 3
retinoic acid-binding receptor gamma	retinoid-related orphan receptor gamma

Related Diseases

Diseases

Alias

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Nail Disease

Nail Diseases	Abnormality Of The Nail
Nail Anomaly

Hyper Ige Syndrome

Hyper-Ige Syndrome	Hyper Immunoglobulin E Syndrome
Hies	Hyper-Ige Recurrent Infection Syndrome
Hyperimmunoglobulin E Syndrome	Hyper Ige
Job Syndrome	Hartnup Disease

Chronic Mucocutaneous Candidiasis

Candidiasis, Chronic Mucocutaneous	Cmc
Candidiasis Chronic Mucocutaneous

Immunodeficiency 42

Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Rorgamma Receptor Deficiency	IMD42
Autosomal Recessive Msmd Due To Complete Rorgamma Receptor Defiency	Autosomal Recessive Primary Immunodeficiency Due To Rorc Mutation

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behet'S Syndrome
Bd Syndrome	Behçet Syndrome
Behçet'S Disease	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Candidiasis

Systemic Candidiasis	Invasive Candidiasis
Disseminated Candidiasis	Systemic Candida Infections
Candidiasis, Invasive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112706	PF-06747711	Antagonist	99.86%	Unkown
HY-19775	GNE-6468		98.04%	Unkown
HY-19774	GNE-0946		98.09%	Unkown
HY-128353	ROR agonist-1	Antagonist	/	Unkown
HY-148237	JNJ-54119936		/	Unkown
HY-RS12132	RORC Human Pre-designed siRNA Set A		/	Unkown
HY-RS12133	Rorc Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS12134	Rorc Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RORC	VGNC	VGNC:45697
Rattus norvegicus	RORC	RGD	RGD:1595785
Mus musculus	RORC	MGD	MGI:104856
Bos taurus	RORC	VGNC	VGNC:34090
Macaca mulatta	RORC	VGNC	VGNC:76719
Felis catus	RORC	VGNC	VGNC:64723
Others	RORC	NCBI

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