RORC - RAR related orphan receptor C Gene

Also Known as TOR; RORG; RZRG; IMD42; NR1F3; RZR-GAMMA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6097

About RORC

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,806,071-151,831,802 (from NCBI)

This gene has 11 transcripts (splice variants), 383 orthologues, 18 paralogues and is associated with 2 phenotypes. Broad expression in liver (RPKM 16.0), thyroid (RPKM 15.9) and 18 other tissues.

Summary

The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RORC Products (4)

mRNA Protein Name
NM_001001523.2 NP_001001523.1 nuclear receptor ROR-gamma isoform b
NM_005060.4 NP_005051.2 nuclear receptor ROR-gamma isoform a
XM_006711484.5 XP_006711547.3 nuclear receptor ROR-gamma isoform X2
XM_047427201.1 XP_047283157.1 nuclear receptor ROR-gamma isoform X1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
20427770 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
20427770 GOA
enables ligand-activated transcription factor activity IDA
IDA: Inferred from direct assay
19965867 GOA
enables oxysterol binding IDA
IDA: Inferred from direct assay
19965867 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18368049 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to sterol IDA
IDA: Inferred from direct assay
19965867 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
20427770 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
19965867 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RORC Protein Structure

zf-C4

zf-C4: Zinc finger, C4 type (two domains) (30 - 98)

Hormone_recep

Hormone_recep: Ligand-binding domain of nuclear hormone receptor (315 - 459)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 518 a.a.
Protein Preferred Names Protein Names

nuclear receptor ROR-gamma

  • nuclear receptor RZR-gamma

  • nuclear receptor subfamily 1 group F member 3

  • retinoic acid-binding receptor gamma

  • retinoid-related orphan receptor gamma

RORC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RORC P51449 PSMC5 Homo sapiens P62195
Validated Y2H
32296183
Intra
RORC P51449 NCOA1 Homo sapiens Q15788
Alpha-Screen
20203100
Cross
RORC P51449 Clock Mus musculus O08785
Anti Tag CoIP
23555304
Cross: Cross-species interaction Intra: Intraspecies interaction

RORC Antibodies

Cat. No. Product Name Application Reactivity
HY-P83758 ROR gamma T Antibody (YA3559) WB, IHC-P Human, Rat

Related Diseases

Diseases Alias
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Nail Disease

  • Nail Diseases

  • Abnormality Of The Nail

  • Nail Anomaly
Hyper Ige Syndrome

  • Hyper-Ige Syndrome

  • Hyper Immunoglobulin E Syndrome

  • Hies

  • Hyper-Ige Recurrent Infection Syndrome

  • Hyperimmunoglobulin E Syndrome

  • Hyper Ige

  • Job Syndrome

  • Hartnup Disease
Chronic Mucocutaneous Candidiasis

  • Candidiasis, Chronic Mucocutaneous

  • Cmc

  • Candidiasis Chronic Mucocutaneous
Immunodeficiency 42

  • Autosomal Recessive Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Rorgamma Receptor Deficiency

  • IMD42

  • Autosomal Recessive Msmd Due To Complete Rorgamma Receptor Defiency

  • Autosomal Recessive Primary Immunodeficiency Due To Rorc Mutation
Behcet Syndrome

  • Behcet Disease

  • Behcet'S Syndrome

  • Behcet'S Disease

  • Behçet Disease

  • Bd

  • Adamantiades-Behcet Disease

  • Triple Symptom Complex

  • Behet'S Syndrome

  • Bd Syndrome

  • Behçet Syndrome

  • Behçet'S Disease

  • Behçet'S Syndrome

  • Behcet Triple Symptom Complex

  • Malignant Aphthosis

  • Old Silk Route Disease

  • Adamantiades-Behçet Disease
Candidiasis

  • Systemic Candidiasis

  • Invasive Candidiasis

  • Disseminated Candidiasis

  • Systemic Candida Infections

  • Candidiasis, Invasive
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19775 GNE-6468 Antagonist 98.02% Unkown
HY-112706 PF-06747711 Antagonist 99.83% Unkown
HY-19774 GNE-0946 Inhibitor 98.11% Unkown
HY-16983 GNE-3500 Antagonist 98.90% Unkown
HY-RS12132 RORC Human Pre-designed siRNA Set A / Unkown
HY-128353 ROR agonist-1 Antagonist / Unkown
HY-148237 JNJ-54119936 Antagonist / Unkown
HY-RS12133 Rorc Mouse Pre-designed siRNA Set A / Unkown
HY-RS12134 Rorc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180865 RORC modulator-1 / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RORC VGNC VGNC:45697
Rattus norvegicus RORC RGD RGD:1595785
Mus musculus RORC MGD MGI:104856
Bos taurus RORC VGNC VGNC:34090
Macaca mulatta RORC VGNC VGNC:76719
Felis catus RORC VGNC VGNC:64723
Others RORC NCBI